Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZIC3Zic family member 3. (466 aa)    
Predicted Functional Partners:
ZIC5
Zic family member 5.
   
  
 0.945
ZIC1
Zic family member 1.
   
    0.926
APP
Amyloid beta precursor protein.
      
 0.888
NODAL
Nodal growth differentiation factor.
    
 
 0.675
ACVR2B
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.673
ABCA1
ATP binding cassette subfamily A member 1.
    
 
 0.646
TDGF1
Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
    
 0.576
GLI3
GLI family zinc finger 3.
    
   0.550
CFC1
EGF-like domain-containing protein.
    
 0.527
NANOG
Nanog homeobox.
    
 0.520
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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