| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCAR2 | SIRT1 | ENSCSAP00000012418 | ENSCSAP00000003766 | Cell cycle and apoptosis regulator 2. | Sirtuin 1. | 0.998 |
| FOXO1 | FOXO3 | ENSCSAP00000013863 | ENSCSAP00000011269 | Forkhead box O1. | Forkhead box O3. | 0.976 |
| FOXO1 | PPARG | ENSCSAP00000013863 | ENSCSAP00000006082 | Forkhead box O1. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.660 |
| FOXO1 | PPARGC1A | ENSCSAP00000013863 | ENSCSAP00000012633 | Forkhead box O1. | PPARG coactivator 1 alpha. | 0.992 |
| FOXO1 | SIRT1 | ENSCSAP00000013863 | ENSCSAP00000003766 | Forkhead box O1. | Sirtuin 1. | 0.997 |
| FOXO1 | SIRT6 | ENSCSAP00000013863 | ENSCSAP00000006979 | Forkhead box O1. | Sirtuin 6. | 0.589 |
| FOXO1 | SIRT7 | ENSCSAP00000013863 | ENSCSAP00000015834 | Forkhead box O1. | Sirtuin 7. | 0.412 |
| FOXO1 | TP53 | ENSCSAP00000013863 | ENSCSAP00000007551 | Forkhead box O1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.821 |
| FOXO3 | FOXO1 | ENSCSAP00000011269 | ENSCSAP00000013863 | Forkhead box O3. | Forkhead box O1. | 0.976 |
| FOXO3 | PPARG | ENSCSAP00000011269 | ENSCSAP00000006082 | Forkhead box O3. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.486 |
| FOXO3 | PPARGC1A | ENSCSAP00000011269 | ENSCSAP00000012633 | Forkhead box O3. | PPARG coactivator 1 alpha. | 0.791 |
| FOXO3 | SIRT1 | ENSCSAP00000011269 | ENSCSAP00000003766 | Forkhead box O3. | Sirtuin 1. | 0.996 |
| FOXO3 | SIRT6 | ENSCSAP00000011269 | ENSCSAP00000006979 | Forkhead box O3. | Sirtuin 6. | 0.591 |
| FOXO3 | SIRT7 | ENSCSAP00000011269 | ENSCSAP00000015834 | Forkhead box O3. | Sirtuin 7. | 0.413 |
| FOXO3 | TP53 | ENSCSAP00000011269 | ENSCSAP00000007551 | Forkhead box O3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.902 |
| NAMPT | PPARG | ENSCSAP00000007630 | ENSCSAP00000006082 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.403 |
| NAMPT | SIRT1 | ENSCSAP00000007630 | ENSCSAP00000003766 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 1. | 0.966 |
| NAMPT | SIRT6 | ENSCSAP00000007630 | ENSCSAP00000006979 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 6. | 0.946 |
| NAMPT | SIRT7 | ENSCSAP00000007630 | ENSCSAP00000015834 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 7. | 0.938 |
| PPARG | FOXO1 | ENSCSAP00000006082 | ENSCSAP00000013863 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Forkhead box O1. | 0.660 |
