STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1754 aa)    
Predicted Functional Partners:
GPIHBP1
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1.
   
 0.820
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
     
 0.804
PCSK9
Proprotein convertase subtilisin/kexin type 9.
      
 0.781
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
    
 0.764
BSND
Barttin CLCNK type accessory beta subunit.
      
 0.728
USP24
Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.
      
 0.714
SCG5
Secretogranin V.
   
 
 0.706
LDLR
Low density lipoprotein receptor.
      
 0.673
LIPN
Lipase; Belongs to the AB hydrolase superfamily. Lipase family.
  
  
 0.620
GDF11
Growth differentiation factor 11.
    
 0.566
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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