Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ICOSLGUncharacterized protein. (302 aa)    
Predicted Functional Partners:
ICOS
Inducible T cell costimulator.
   
 0.999
CD28
CD28 molecule.
   
 0.952
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
    
 0.945
ACVRL1
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.625
CD4
CD4 molecule.
    
 0.615
MPZL1
Myelin protein zero like 1.
    
 
 0.600
JAM3
Junctional adhesion molecule 3.
      
 0.574
TNFSF9
TNF superfamily member 9; Belongs to the tumor necrosis factor family.
  
   
 0.553
PANX1
Pannexin; Structural component of the gap junctions and the hemichannels.
    
 
 0.523
PTPRM
Protein tyrosine phosphatase receptor type M.
   
  
 0.516
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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