Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)    
Predicted Functional Partners:
C9orf72
C9orf72-SMCR8 complex subunit.
    
 0.996
WDR41
WD repeat domain 41.
    
 0.995
RAB39B
RAB39B, member RAS oncogene family.
    
 0.954
ULK1
Unc-51 like autophagy activating kinase 1.
    
 0.953
ULK2
Unc-51 like autophagy activating kinase 2.
    
 0.949
RAB8A
RAB8A, member RAS oncogene family.
    
 0.947
TBK1
TANK binding kinase 1.
   
 0.929
TANK
TRAF family member associated NFKB activator.
     
 0.912
ARF1
ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.799
IMPDH2
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
    
   0.795
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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