STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CD274CD274 molecule. (291 aa)    
Predicted Functional Partners:
PDCD1
Programmed cell death 1.
   
 0.996
CD80
Ig-like domain-containing protein.
   
 0.961
CD4
CD4 molecule.
     
 0.703
LAG3
Lymphocyte activating 3.
   
 
 0.694
JAK1
Tyrosine-protein kinase.
   
 
 0.683
IDO1
Indoleamine 2,3-dioxygenase 1.
   
  
 0.682
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
 
 0.670
TIGIT
T cell immunoreceptor with Ig and ITIM domains.
      
 0.665
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.625
FOXP3
Forkhead box P3.
    
 
 0.607
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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