STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FGFR4Fibroblast growth factor receptor. (806 aa)    
Predicted Functional Partners:
FGF19
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.993
FGF1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.991
FGF2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 0.990
FGF23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
    
 0.979
KLB
Klotho beta.
    
 0.979
GRB2
Growth factor receptor bound protein 2.
   
 0.968
FGF6
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.962
FGF4
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.957
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.956
FGFR1
Fibroblast growth factor receptor.
   
 0.956
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.