STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NLRP3NLR family pyrin domain containing 3. (1035 aa)    
Predicted Functional Partners:
PYCARD
PYD and CARD domain containing.
   
 0.982
TXNIP
Thioredoxin interacting protein.
     
 0.979
NEK7
NIMA related kinase 7; Belongs to the protein kinase superfamily.
    
 0.973
MAVS
Mitochondrial antiviral signaling protein.
    
 0.964
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
 0.957
CASP1
Caspase 1; Belongs to the peptidase C14A family.
   
 0.951
ENSCSAP00000014978
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.951
SUGT1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.
    
 0.941
GSDMD
Gasdermin D.
     
 0.939
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
   
 
 0.935
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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