| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COX1 | COX10 | ENSCSAP00000000003 | ENSCSAP00000005279 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | 0.955 |
| COX1 | COX11 | ENSCSAP00000000003 | ENSCSAP00000001846 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | Cytochrome c oxidase copper chaperone COX11. | 0.872 |
| COX1 | COX15 | ENSCSAP00000000003 | ENSCSAP00000002022 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | Cytochrome c oxidase assembly homolog COX15. | 0.913 |
| COX1 | COX2 | ENSCSAP00000000003 | ENSCSAP00000000004 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. | 0.999 |
| COX1 | COX3 | ENSCSAP00000000003 | ENSCSAP00000000007 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. | 0.999 |
| COX1 | COX5A | ENSCSAP00000000003 | ENSCSAP00000010475 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | Cytochrome c oxidase subunit 5A. | 0.987 |
| COX1 | SURF1 | ENSCSAP00000000003 | ENSCSAP00000011315 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. | 0.882 |
| COX10 | COX1 | ENSCSAP00000005279 | ENSCSAP00000000003 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | 0.955 |
| COX10 | COX11 | ENSCSAP00000005279 | ENSCSAP00000001846 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c oxidase copper chaperone COX11. | 0.895 |
| COX10 | COX15 | ENSCSAP00000005279 | ENSCSAP00000002022 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c oxidase assembly homolog COX15. | 0.997 |
| COX10 | COX2 | ENSCSAP00000005279 | ENSCSAP00000000004 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. | 0.918 |
| COX10 | COX3 | ENSCSAP00000005279 | ENSCSAP00000000007 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. | 0.950 |
| COX10 | COX5A | ENSCSAP00000005279 | ENSCSAP00000010475 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c oxidase subunit 5A. | 0.761 |
| COX10 | FECH | ENSCSAP00000005279 | ENSCSAP00000014166 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.944 |
| COX10 | HCCS | ENSCSAP00000005279 | ENSCSAP00000011358 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.943 |
| COX10 | HMOX1 | ENSCSAP00000005279 | ENSCSAP00000004458 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | Heme oxygenase 1. | 0.907 |
| COX10 | SURF1 | ENSCSAP00000005279 | ENSCSAP00000011315 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. | 0.868 |
| COX11 | COX1 | ENSCSAP00000001846 | ENSCSAP00000000003 | Cytochrome c oxidase copper chaperone COX11. | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. | 0.872 |
| COX11 | COX10 | ENSCSAP00000001846 | ENSCSAP00000005279 | Cytochrome c oxidase copper chaperone COX11. | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. | 0.895 |
| COX11 | COX15 | ENSCSAP00000001846 | ENSCSAP00000002022 | Cytochrome c oxidase copper chaperone COX11. | Cytochrome c oxidase assembly homolog COX15. | 0.871 |