| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HDAC3 | KDM1A | ENSCSAP00000008654 | ENSCSAP00000017088 | Hist_deacetyl domain-containing protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.914 |
| HDAC3 | MED1 | ENSCSAP00000008654 | ENSCSAP00000015361 | Hist_deacetyl domain-containing protein. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.545 |
| HDAC3 | NCOR1 | ENSCSAP00000008654 | ENSCSAP00000004853 | Hist_deacetyl domain-containing protein. | Nuclear receptor corepressor 1. | 0.999 |
| HDAC3 | NCOR2 | ENSCSAP00000008654 | ENSCSAP00000016047 | Hist_deacetyl domain-containing protein. | Nuclear receptor corepressor 2. | 0.991 |
| HDAC3 | NR2C2 | ENSCSAP00000008654 | ENSCSAP00000005460 | Hist_deacetyl domain-containing protein. | Nuclear receptor subfamily 2 group C member 2. | 0.656 |
| HDAC3 | NRIP1 | ENSCSAP00000008654 | ENSCSAP00000018230 | Hist_deacetyl domain-containing protein. | Nuclear receptor interacting protein 1. | 0.634 |
| HDAC3 | UBE2I | ENSCSAP00000008654 | ENSCSAP00000007972 | Hist_deacetyl domain-containing protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.401 |
| JAZF1 | NR2C2 | ENSCSAP00000010486 | ENSCSAP00000005460 | JAZF zinc finger 1. | Nuclear receptor subfamily 2 group C member 2. | 0.797 |
| KDM1A | HDAC3 | ENSCSAP00000017088 | ENSCSAP00000008654 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Hist_deacetyl domain-containing protein. | 0.914 |
| KDM1A | NR2C2 | ENSCSAP00000017088 | ENSCSAP00000005460 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Nuclear receptor subfamily 2 group C member 2. | 0.624 |
| MED1 | HDAC3 | ENSCSAP00000015361 | ENSCSAP00000008654 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Hist_deacetyl domain-containing protein. | 0.545 |
| MED1 | NCOR1 | ENSCSAP00000015361 | ENSCSAP00000004853 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 1. | 0.676 |
| MED1 | NCOR2 | ENSCSAP00000015361 | ENSCSAP00000016047 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 2. | 0.656 |
| MED1 | NR2C2 | ENSCSAP00000015361 | ENSCSAP00000005460 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 2 group C member 2. | 0.677 |
| NCOR1 | HDAC3 | ENSCSAP00000004853 | ENSCSAP00000008654 | Nuclear receptor corepressor 1. | Hist_deacetyl domain-containing protein. | 0.999 |
| NCOR1 | MED1 | ENSCSAP00000004853 | ENSCSAP00000015361 | Nuclear receptor corepressor 1. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.676 |
| NCOR1 | NCOR2 | ENSCSAP00000004853 | ENSCSAP00000016047 | Nuclear receptor corepressor 1. | Nuclear receptor corepressor 2. | 0.973 |
| NCOR1 | NR2C2 | ENSCSAP00000004853 | ENSCSAP00000005460 | Nuclear receptor corepressor 1. | Nuclear receptor subfamily 2 group C member 2. | 0.667 |
| NCOR1 | NRIP1 | ENSCSAP00000004853 | ENSCSAP00000018230 | Nuclear receptor corepressor 1. | Nuclear receptor interacting protein 1. | 0.469 |
| NCOR1 | TAB2 | ENSCSAP00000004853 | ENSCSAP00000013252 | Nuclear receptor corepressor 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.876 |
