| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APIP | APRT | ENSCSAP00000001736 | ENSCSAP00000015145 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Adenine phosphoribosyltransferase. | 0.441 |
| APIP | MRI1 | ENSCSAP00000001736 | ENSCSAP00000002739 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.984 |
| APIP | MTAP | ENSCSAP00000001736 | ENSCSAP00000005938 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.658 |
| APRT | APIP | ENSCSAP00000015145 | ENSCSAP00000001736 | Adenine phosphoribosyltransferase. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.441 |
| APRT | GMPS | ENSCSAP00000015145 | ENSCSAP00000008209 | Adenine phosphoribosyltransferase. | Guanine monophosphate synthase. | 0.767 |
| APRT | LACC1 | ENSCSAP00000015145 | ENSCSAP00000013805 | Adenine phosphoribosyltransferase. | Uncharacterized protein. | 0.922 |
| APRT | MRI1 | ENSCSAP00000015145 | ENSCSAP00000002739 | Adenine phosphoribosyltransferase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.487 |
| APRT | MTAP | ENSCSAP00000015145 | ENSCSAP00000005938 | Adenine phosphoribosyltransferase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.796 |
| APRT | SRM | ENSCSAP00000015145 | ENSCSAP00000017219 | Adenine phosphoribosyltransferase. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.417 |
| EPHX2 | MTAP | ENSCSAP00000012060 | ENSCSAP00000005938 | Epoxide hydrolase 2. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.852 |
| GMPS | APRT | ENSCSAP00000008209 | ENSCSAP00000015145 | Guanine monophosphate synthase. | Adenine phosphoribosyltransferase. | 0.767 |
| GMPS | MTAP | ENSCSAP00000008209 | ENSCSAP00000005938 | Guanine monophosphate synthase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.803 |
| LACC1 | APRT | ENSCSAP00000013805 | ENSCSAP00000015145 | Uncharacterized protein. | Adenine phosphoribosyltransferase. | 0.922 |
| LACC1 | MRI1 | ENSCSAP00000013805 | ENSCSAP00000002739 | Uncharacterized protein. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.903 |
| LACC1 | MTAP | ENSCSAP00000013805 | ENSCSAP00000005938 | Uncharacterized protein. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.915 |
| LACC1 | SMS | ENSCSAP00000013805 | ENSCSAP00000010563 | Uncharacterized protein. | Spermine synthase. | 0.901 |
| LACC1 | SRM | ENSCSAP00000013805 | ENSCSAP00000017219 | Uncharacterized protein. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.901 |
| MRI1 | APIP | ENSCSAP00000002739 | ENSCSAP00000001736 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.984 |
| MRI1 | APRT | ENSCSAP00000002739 | ENSCSAP00000015145 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Adenine phosphoribosyltransferase. | 0.487 |
| MRI1 | LACC1 | ENSCSAP00000002739 | ENSCSAP00000013805 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Uncharacterized protein. | 0.903 |
