| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APRT | GMPS | ENSCSAP00000015145 | ENSCSAP00000008209 | Adenine phosphoribosyltransferase. | Guanine monophosphate synthase. | 0.991 |
| APRT | MRI1 | ENSCSAP00000015145 | ENSCSAP00000002739 | Adenine phosphoribosyltransferase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.486 |
| APRT | MTAP | ENSCSAP00000015145 | ENSCSAP00000005938 | Adenine phosphoribosyltransferase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.930 |
| APRT | NT5E | ENSCSAP00000015145 | ENSCSAP00000013406 | Adenine phosphoribosyltransferase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.957 |
| APRT | UPP1 | ENSCSAP00000015145 | ENSCSAP00000011906 | Adenine phosphoribosyltransferase. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.866 |
| EPHX2 | MTAP | ENSCSAP00000012060 | ENSCSAP00000005938 | Epoxide hydrolase 2. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.874 |
| EPHX2 | NT5E | ENSCSAP00000012060 | ENSCSAP00000013406 | Epoxide hydrolase 2. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.846 |
| EPHX2 | OGG1 | ENSCSAP00000012060 | ENSCSAP00000006823 | Epoxide hydrolase 2. | 8-oxoguanine DNA glycosylase. | 0.519 |
| GMPS | APRT | ENSCSAP00000008209 | ENSCSAP00000015145 | Guanine monophosphate synthase. | Adenine phosphoribosyltransferase. | 0.991 |
| GMPS | MTAP | ENSCSAP00000008209 | ENSCSAP00000005938 | Guanine monophosphate synthase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.911 |
| GMPS | NT5E | ENSCSAP00000008209 | ENSCSAP00000013406 | Guanine monophosphate synthase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.923 |
| GMPS | UPP1 | ENSCSAP00000008209 | ENSCSAP00000011906 | Guanine monophosphate synthase. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.617 |
| HDDC2 | MTAP | ENSCSAP00000012378 | ENSCSAP00000005938 | HD domain containing 2. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.816 |
| MRI1 | APRT | ENSCSAP00000002739 | ENSCSAP00000015145 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Adenine phosphoribosyltransferase. | 0.486 |
| MRI1 | MTAP | ENSCSAP00000002739 | ENSCSAP00000005938 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.992 |
| MRI1 | SMS | ENSCSAP00000002739 | ENSCSAP00000010563 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Spermine synthase. | 0.571 |
| MRI1 | SRM | ENSCSAP00000002739 | ENSCSAP00000017219 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.685 |
| MTAP | APRT | ENSCSAP00000005938 | ENSCSAP00000015145 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | Adenine phosphoribosyltransferase. | 0.930 |
| MTAP | EPHX2 | ENSCSAP00000005938 | ENSCSAP00000012060 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | Epoxide hydrolase 2. | 0.874 |
| MTAP | GMPS | ENSCSAP00000005938 | ENSCSAP00000008209 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | Guanine monophosphate synthase. | 0.911 |