| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHCY | CTH | ENSCSAP00000008298 | ENSCSAP00000016641 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Cystathionine gamma-lyase. | 0.945 |
| AHCY | MAT1A | ENSCSAP00000008298 | ENSCSAP00000005644 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.703 |
| AHCY | MTHFR | ENSCSAP00000008298 | ENSCSAP00000017206 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.608 |
| AHCY | MTR | ENSCSAP00000008298 | ENSCSAP00000005947 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
| AHCY | SHMT1 | ENSCSAP00000008298 | ENSCSAP00000004301 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.630 |
| AHCY | SHMT2 | ENSCSAP00000008298 | ENSCSAP00000001251 | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.719 |
| CTH | AHCY | ENSCSAP00000016641 | ENSCSAP00000008298 | Cystathionine gamma-lyase. | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | 0.945 |
| CTH | MAT1A | ENSCSAP00000016641 | ENSCSAP00000005644 | Cystathionine gamma-lyase. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.448 |
| CTH | MTHFR | ENSCSAP00000016641 | ENSCSAP00000017206 | Cystathionine gamma-lyase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.921 |
| CTH | MTR | ENSCSAP00000016641 | ENSCSAP00000005947 | Cystathionine gamma-lyase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.981 |
| CTH | MTRR | ENSCSAP00000016641 | ENSCSAP00000013365 | Cystathionine gamma-lyase. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.679 |
| CTH | SHMT2 | ENSCSAP00000016641 | ENSCSAP00000001251 | Cystathionine gamma-lyase. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.418 |
| DMGDH | MTHFD1 | ENSCSAP00000011351 | ENSCSAP00000009961 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. | 0.931 |
| DMGDH | MTHFD1L | ENSCSAP00000011351 | ENSCSAP00000010435 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.940 |
| DMGDH | MTHFR | ENSCSAP00000011351 | ENSCSAP00000017206 | Dimethylglycine dehydrogenase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.976 |
| DMGDH | MTR | ENSCSAP00000011351 | ENSCSAP00000005947 | Dimethylglycine dehydrogenase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.966 |
| DMGDH | SHMT1 | ENSCSAP00000011351 | ENSCSAP00000004301 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.981 |
| DMGDH | SHMT2 | ENSCSAP00000011351 | ENSCSAP00000001251 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.981 |
| MAT1A | AHCY | ENSCSAP00000005644 | ENSCSAP00000008298 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. | 0.703 |
| MAT1A | CTH | ENSCSAP00000005644 | ENSCSAP00000016641 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Cystathionine gamma-lyase. | 0.448 |
