| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGF | EGFR | ENSCSAP00000000280 | ENSCSAP00000012126 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Receptor protein-tyrosine kinase. | 0.999 |
| EGF | FGFR4 | ENSCSAP00000000280 | ENSCSAP00000005196 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Fibroblast growth factor receptor. | 0.709 |
| EGF | IGF1 | ENSCSAP00000000280 | ENSCSAP00000014754 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Insulin like growth factor 1. | 0.971 |
| EGF | IGF1R | ENSCSAP00000000280 | ENSCSAP00000012999 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Tyrosine-protein kinase receptor. | 0.967 |
| EGF | INS | ENSCSAP00000000280 | ENSCSAP00000006039 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.988 |
| EGF | INSR | ENSCSAP00000000280 | ENSCSAP00000005091 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Tyrosine-protein kinase receptor. | 0.458 |
| EGF | KIT | ENSCSAP00000000280 | ENSCSAP00000001313 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.934 |
| EGFR | EGF | ENSCSAP00000012126 | ENSCSAP00000000280 | Receptor protein-tyrosine kinase. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.999 |
| EGFR | IGF1 | ENSCSAP00000012126 | ENSCSAP00000014754 | Receptor protein-tyrosine kinase. | Insulin like growth factor 1. | 0.949 |
| EGFR | IGF1R | ENSCSAP00000012126 | ENSCSAP00000012999 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.975 |
| EGFR | INS | ENSCSAP00000012126 | ENSCSAP00000006039 | Receptor protein-tyrosine kinase. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.952 |
| EGFR | INSR | ENSCSAP00000012126 | ENSCSAP00000005091 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.434 |
| FGFR4 | EGF | ENSCSAP00000005196 | ENSCSAP00000000280 | Fibroblast growth factor receptor. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.709 |
| FGFR4 | IGF1 | ENSCSAP00000005196 | ENSCSAP00000014754 | Fibroblast growth factor receptor. | Insulin like growth factor 1. | 0.683 |
| FGFR4 | INS | ENSCSAP00000005196 | ENSCSAP00000006039 | Fibroblast growth factor receptor. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.935 |
| IDE | INS | ENSCSAP00000002854 | ENSCSAP00000006039 | Insulin degrading enzyme; Belongs to the peptidase M16 family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.968 |
| IGF1 | EGF | ENSCSAP00000014754 | ENSCSAP00000000280 | Insulin like growth factor 1. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.971 |
| IGF1 | EGFR | ENSCSAP00000014754 | ENSCSAP00000012126 | Insulin like growth factor 1. | Receptor protein-tyrosine kinase. | 0.949 |
| IGF1 | FGFR4 | ENSCSAP00000014754 | ENSCSAP00000005196 | Insulin like growth factor 1. | Fibroblast growth factor receptor. | 0.683 |
| IGF1 | IGF1R | ENSCSAP00000014754 | ENSCSAP00000012999 | Insulin like growth factor 1. | Tyrosine-protein kinase receptor. | 0.999 |