| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HGS | MVB12A | ENSCSAP00000015796 | ENSCSAP00000001909 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Multivesicular body subunit 12A. | 0.806 |
| HGS | SNF8 | ENSCSAP00000015796 | ENSCSAP00000015550 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.862 |
| HGS | STAM | ENSCSAP00000015796 | ENSCSAP00000008819 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Signal transducing adaptor molecule. | 0.999 |
| HGS | TSG101 | ENSCSAP00000015796 | ENSCSAP00000001374 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Tumor susceptibility 101. | 0.998 |
| HGS | UBAP1 | ENSCSAP00000015796 | ENSCSAP00000006260 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Ubiquitin associated protein 1. | 0.933 |
| HGS | VPS25 | ENSCSAP00000015796 | ENSCSAP00000014711 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar protein sorting 25 homolog. | 0.862 |
| HGS | VPS28 | ENSCSAP00000015796 | ENSCSAP00000004690 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. | 0.968 |
| HGS | VPS36 | ENSCSAP00000015796 | ENSCSAP00000013687 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | Vacuolar protein sorting 36 homolog. | 0.871 |
| HGS | VPS37A | ENSCSAP00000015796 | ENSCSAP00000012830 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | VPS37A subunit of ESCRT-I. | 0.930 |
| HGS | VPS37B | ENSCSAP00000015796 | ENSCSAP00000015952 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | VPS37B subunit of ESCRT-I. | 0.855 |
| MVB12A | HGS | ENSCSAP00000001909 | ENSCSAP00000015796 | Multivesicular body subunit 12A. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.806 |
| MVB12A | SNF8 | ENSCSAP00000001909 | ENSCSAP00000015550 | Multivesicular body subunit 12A. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.855 |
| MVB12A | STAM | ENSCSAP00000001909 | ENSCSAP00000008819 | Multivesicular body subunit 12A. | Signal transducing adaptor molecule. | 0.852 |
| MVB12A | TSG101 | ENSCSAP00000001909 | ENSCSAP00000001374 | Multivesicular body subunit 12A. | Tumor susceptibility 101. | 0.986 |
| MVB12A | UBAP1 | ENSCSAP00000001909 | ENSCSAP00000006260 | Multivesicular body subunit 12A. | Ubiquitin associated protein 1. | 0.967 |
| MVB12A | VPS25 | ENSCSAP00000001909 | ENSCSAP00000014711 | Multivesicular body subunit 12A. | Vacuolar protein sorting 25 homolog. | 0.925 |
| MVB12A | VPS28 | ENSCSAP00000001909 | ENSCSAP00000004690 | Multivesicular body subunit 12A. | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. | 0.991 |
| MVB12A | VPS36 | ENSCSAP00000001909 | ENSCSAP00000013687 | Multivesicular body subunit 12A. | Vacuolar protein sorting 36 homolog. | 0.832 |
| MVB12A | VPS37A | ENSCSAP00000001909 | ENSCSAP00000012830 | Multivesicular body subunit 12A. | VPS37A subunit of ESCRT-I. | 0.992 |
| MVB12A | VPS37B | ENSCSAP00000001909 | ENSCSAP00000015952 | Multivesicular body subunit 12A. | VPS37B subunit of ESCRT-I. | 0.993 |
