| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMD1 | DNMT1 | ENSCSAP00000011624 | ENSCSAP00000003647 | Adenosylmethionine decarboxylase 1. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.904 |
| AMD1 | GNMT | ENSCSAP00000011624 | ENSCSAP00000007708 | Adenosylmethionine decarboxylase 1. | Glycine N-methyltransferase. | 0.937 |
| AMD1 | MAT1A | ENSCSAP00000011624 | ENSCSAP00000005644 | Adenosylmethionine decarboxylase 1. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.944 |
| AMD1 | MAT2A | ENSCSAP00000011624 | ENSCSAP00000012240 | Adenosylmethionine decarboxylase 1. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.944 |
| AMD1 | MAT2B | ENSCSAP00000011624 | ENSCSAP00000006477 | Adenosylmethionine decarboxylase 1. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.917 |
| AMD1 | MTR | ENSCSAP00000011624 | ENSCSAP00000005947 | Adenosylmethionine decarboxylase 1. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.521 |
| AMD1 | TAT | ENSCSAP00000011624 | ENSCSAP00000000628 | Adenosylmethionine decarboxylase 1. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.482 |
| BHMT | BHMT2 | ENSCSAP00000011339 | ENSCSAP00000011344 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | 0.901 |
| BHMT | GNMT | ENSCSAP00000011339 | ENSCSAP00000007708 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Glycine N-methyltransferase. | 0.500 |
| BHMT | IL4I1 | ENSCSAP00000011339 | ENSCSAP00000015627 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Amine oxidase. | 0.900 |
| BHMT | MAT1A | ENSCSAP00000011339 | ENSCSAP00000005644 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.963 |
| BHMT | MAT2A | ENSCSAP00000011339 | ENSCSAP00000012240 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.963 |
| BHMT | MAT2B | ENSCSAP00000011339 | ENSCSAP00000006477 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.936 |
| BHMT | MTR | ENSCSAP00000011339 | ENSCSAP00000005947 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.945 |
| BHMT | TAT | ENSCSAP00000011339 | ENSCSAP00000000628 | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.935 |
| BHMT2 | BHMT | ENSCSAP00000011344 | ENSCSAP00000011339 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. | 0.901 |
| BHMT2 | GNMT | ENSCSAP00000011344 | ENSCSAP00000007708 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Glycine N-methyltransferase. | 0.500 |
| BHMT2 | IL4I1 | ENSCSAP00000011344 | ENSCSAP00000015627 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | Amine oxidase. | 0.900 |
| BHMT2 | MAT1A | ENSCSAP00000011344 | ENSCSAP00000005644 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.963 |
| BHMT2 | MAT2A | ENSCSAP00000011344 | ENSCSAP00000012240 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.963 |
