| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD4 | CD8A | ENSCSAP00000006497 | ENSCSAP00000012425 | CD4 molecule. | CD8a molecule. | 0.984 |
| CD4 | CD8B | ENSCSAP00000006497 | ENSCSAP00000012431 | CD4 molecule. | Ig-like domain-containing protein. | 0.981 |
| CD4 | CUL1 | ENSCSAP00000006497 | ENSCSAP00000003333 | CD4 molecule. | Cullin 1; Belongs to the cullin family. | 0.970 |
| CD4 | HLA-DQA1 | ENSCSAP00000006497 | ENSCSAP00000005640 | CD4 molecule. | Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. | 0.962 |
| CD4 | HLA-DRA | ENSCSAP00000006497 | ENSCSAP00000005619 | CD4 molecule. | Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. | 0.973 |
| CD4 | IFNG | ENSCSAP00000006497 | ENSCSAP00000000682 | CD4 molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.955 |
| CD4 | IL16 | ENSCSAP00000006497 | ENSCSAP00000011220 | CD4 molecule. | Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. | 0.974 |
| CD4 | IL2 | ENSCSAP00000006497 | ENSCSAP00000000035 | CD4 molecule. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.964 |
| CD4 | IL4 | ENSCSAP00000006497 | ENSCSAP00000009917 | CD4 molecule. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.962 |
| CD4 | ZAP70 | ENSCSAP00000006497 | ENSCSAP00000013315 | CD4 molecule. | Tyrosine-protein kinase. | 0.987 |
| CD8A | CD4 | ENSCSAP00000012425 | ENSCSAP00000006497 | CD8a molecule. | CD4 molecule. | 0.984 |
| CD8A | CD8B | ENSCSAP00000012425 | ENSCSAP00000012431 | CD8a molecule. | Ig-like domain-containing protein. | 0.999 |
| CD8A | IFNG | ENSCSAP00000012425 | ENSCSAP00000000682 | CD8a molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.820 |
| CD8A | IL2 | ENSCSAP00000012425 | ENSCSAP00000000035 | CD8a molecule. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.730 |
| CD8A | IL4 | ENSCSAP00000012425 | ENSCSAP00000009917 | CD8a molecule. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.699 |
| CD8A | ZAP70 | ENSCSAP00000012425 | ENSCSAP00000013315 | CD8a molecule. | Tyrosine-protein kinase. | 0.967 |
| CD8B | CD4 | ENSCSAP00000012431 | ENSCSAP00000006497 | Ig-like domain-containing protein. | CD4 molecule. | 0.981 |
| CD8B | CD8A | ENSCSAP00000012431 | ENSCSAP00000012425 | Ig-like domain-containing protein. | CD8a molecule. | 0.999 |
| CD8B | IFNG | ENSCSAP00000012431 | ENSCSAP00000000682 | Ig-like domain-containing protein. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.406 |
| CD8B | ZAP70 | ENSCSAP00000012431 | ENSCSAP00000013315 | Ig-like domain-containing protein. | Tyrosine-protein kinase. | 0.928 |
