STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)    
Predicted Functional Partners:
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.998
CCND1
Cyclin D1; Belongs to the cyclin family.
   
 0.998
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.998
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.997
CCND3
Cyclin D3; Belongs to the cyclin family.
   
 0.997
CCND2
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
   
 0.996
CCNA2
Cyclin A2; Belongs to the cyclin family.
    
 0.994
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.994
CCNA1
Cyclin A1; Belongs to the cyclin family.
    
 0.992
SKP2
S-phase kinase associated protein 2.
    
 0.988
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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