| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSS1 | IDH2 | ENSCSAP00000014366 | ENSCSAP00000013159 | Acyl-CoA synthetase short chain family member 1. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.609 |
| ACSS1 | SIRT3 | ENSCSAP00000014366 | ENSCSAP00000007481 | Acyl-CoA synthetase short chain family member 1. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.926 |
| ACSS1 | SIRT5 | ENSCSAP00000014366 | ENSCSAP00000003795 | Acyl-CoA synthetase short chain family member 1. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.432 |
| IDH2 | ACSS1 | ENSCSAP00000013159 | ENSCSAP00000014366 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Acyl-CoA synthetase short chain family member 1. | 0.609 |
| IDH2 | SIRT1 | ENSCSAP00000013159 | ENSCSAP00000003766 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Sirtuin 1. | 0.408 |
| IDH2 | SIRT3 | ENSCSAP00000013159 | ENSCSAP00000007481 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.929 |
| IDH2 | SIRT4 | ENSCSAP00000013159 | ENSCSAP00000015768 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.405 |
| IDH2 | SIRT5 | ENSCSAP00000013159 | ENSCSAP00000003795 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.601 |
| NAMPT | NMNAT3 | ENSCSAP00000007630 | ENSCSAP00000007379 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Nicotinamide-nucleotide adenylyltransferase. | 0.960 |
| NAMPT | SARM1 | ENSCSAP00000007630 | ENSCSAP00000003569 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sterile alpha and TIR motif containing 1. | 0.933 |
| NAMPT | SIRT1 | ENSCSAP00000007630 | ENSCSAP00000003766 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 1. | 0.966 |
| NAMPT | SIRT3 | ENSCSAP00000007630 | ENSCSAP00000007481 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.953 |
| NAMPT | SIRT4 | ENSCSAP00000007630 | ENSCSAP00000015768 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.950 |
| NAMPT | SIRT5 | ENSCSAP00000007630 | ENSCSAP00000003795 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.940 |
| NAMPT | SIRT6 | ENSCSAP00000007630 | ENSCSAP00000006979 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 6. | 0.946 |
| NAMPT | SIRT7 | ENSCSAP00000007630 | ENSCSAP00000015834 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 7. | 0.938 |
| NMNAT3 | NAMPT | ENSCSAP00000007379 | ENSCSAP00000007630 | Nicotinamide-nucleotide adenylyltransferase. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.960 |
| NMNAT3 | SARM1 | ENSCSAP00000007379 | ENSCSAP00000003569 | Nicotinamide-nucleotide adenylyltransferase. | Sterile alpha and TIR motif containing 1. | 0.973 |
| NMNAT3 | SIRT1 | ENSCSAP00000007379 | ENSCSAP00000003766 | Nicotinamide-nucleotide adenylyltransferase. | Sirtuin 1. | 0.940 |
| NMNAT3 | SIRT3 | ENSCSAP00000007379 | ENSCSAP00000007481 | Nicotinamide-nucleotide adenylyltransferase. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.926 |
