STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)    
Predicted Functional Partners:
NMNAT2
Nicotinamide nucleotide adenylyltransferase 2.
   
 
 0.965
SIRT1
Sirtuin 1.
   
 
 0.963
NMNAT3
Nicotinamide-nucleotide adenylyltransferase.
   
 
 0.961
SIRT3
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.
     
 0.960
SIRT6
Sirtuin 6.
     
 0.959
SIRT4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]
     
 0.959
NMRK1
Nicotinamide riboside kinase 1.
  
 
 0.958
SIRT7
Sirtuin 7.
     
 0.938
SIRT2
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.
     
 0.934
BST1
Bone marrow stromal cell antigen 1.
     
 0.927
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.