| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFLAR | ITCH | ENSCSAP00000007020 | ENSCSAP00000008281 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | E3 ubiquitin-protein ligase. | 0.993 |
| CFLAR | WWP1 | ENSCSAP00000007020 | ENSCSAP00000009205 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | WW domain containing E3 ubiquitin protein ligase 1. | 0.493 |
| ITCH | CFLAR | ENSCSAP00000008281 | ENSCSAP00000007020 | E3 ubiquitin-protein ligase. | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | 0.993 |
| ITCH | MAPK10 | ENSCSAP00000008281 | ENSCSAP00000000688 | E3 ubiquitin-protein ligase. | Mitogen-activated protein kinase. | 0.952 |
| ITCH | NOTCH1 | ENSCSAP00000008281 | ENSCSAP00000011949 | E3 ubiquitin-protein ligase. | Notch receptor 1. | 0.971 |
| ITCH | NOTCH2 | ENSCSAP00000008281 | ENSCSAP00000016288 | E3 ubiquitin-protein ligase. | Notch receptor 2. | 0.939 |
| ITCH | NOTCH3 | ENSCSAP00000008281 | ENSCSAP00000002446 | E3 ubiquitin-protein ligase. | Notch receptor 3. | 0.939 |
| ITCH | NUMB | ENSCSAP00000008281 | ENSCSAP00000008902 | E3 ubiquitin-protein ligase. | NUMB endocytic adaptor protein. | 0.963 |
| ITCH | RNF11 | ENSCSAP00000008281 | ENSCSAP00000016751 | E3 ubiquitin-protein ligase. | Ring finger protein 11. | 0.955 |
| ITCH | TP63 | ENSCSAP00000008281 | ENSCSAP00000005295 | E3 ubiquitin-protein ligase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.961 |
| ITCH | TP73 | ENSCSAP00000008281 | ENSCSAP00000017283 | E3 ubiquitin-protein ligase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.968 |
| ITCH | WWP1 | ENSCSAP00000008281 | ENSCSAP00000009205 | E3 ubiquitin-protein ligase. | WW domain containing E3 ubiquitin protein ligase 1. | 0.949 |
| MAPK10 | ITCH | ENSCSAP00000000688 | ENSCSAP00000008281 | Mitogen-activated protein kinase. | E3 ubiquitin-protein ligase. | 0.952 |
| MAPK10 | TP63 | ENSCSAP00000000688 | ENSCSAP00000005295 | Mitogen-activated protein kinase. | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. | 0.403 |
| MAPK10 | TP73 | ENSCSAP00000000688 | ENSCSAP00000017283 | Mitogen-activated protein kinase. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.403 |
| NOTCH1 | ITCH | ENSCSAP00000011949 | ENSCSAP00000008281 | Notch receptor 1. | E3 ubiquitin-protein ligase. | 0.971 |
| NOTCH1 | NOTCH2 | ENSCSAP00000011949 | ENSCSAP00000016288 | Notch receptor 1. | Notch receptor 2. | 0.986 |
| NOTCH1 | NOTCH3 | ENSCSAP00000011949 | ENSCSAP00000002446 | Notch receptor 1. | Notch receptor 3. | 0.889 |
| NOTCH1 | NUMB | ENSCSAP00000011949 | ENSCSAP00000008902 | Notch receptor 1. | NUMB endocytic adaptor protein. | 0.983 |
| NOTCH1 | WWP1 | ENSCSAP00000011949 | ENSCSAP00000009205 | Notch receptor 1. | WW domain containing E3 ubiquitin protein ligase 1. | 0.599 |
