| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BIRC6 | HERC1 | ENSCSAP00000007781 | ENSCSAP00000008584 | Baculoviral IAP repeat containing 6. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.761 |
| BIRC6 | PIAS4 | ENSCSAP00000007781 | ENSCSAP00000007004 | Baculoviral IAP repeat containing 6. | Protein inhibitor of activated STAT 4. | 0.451 |
| BRCA1 | HERC1 | ENSCSAP00000014651 | ENSCSAP00000008584 | Uncharacterized protein. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.724 |
| BRCA1 | PIAS4 | ENSCSAP00000014651 | ENSCSAP00000007004 | Uncharacterized protein. | Protein inhibitor of activated STAT 4. | 0.800 |
| BRCA1 | RNF8 | ENSCSAP00000014651 | ENSCSAP00000006706 | Uncharacterized protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.737 |
| BRCA1 | TP53 | ENSCSAP00000014651 | ENSCSAP00000007551 | Uncharacterized protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.983 |
| GEM | HERC1 | ENSCSAP00000008910 | ENSCSAP00000008584 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.843 |
| GEM | MDN1 | ENSCSAP00000008910 | ENSCSAP00000013324 | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. | 0.824 |
| HERC1 | BIRC6 | ENSCSAP00000008584 | ENSCSAP00000007781 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Baculoviral IAP repeat containing 6. | 0.761 |
| HERC1 | BRCA1 | ENSCSAP00000008584 | ENSCSAP00000014651 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Uncharacterized protein. | 0.724 |
| HERC1 | GEM | ENSCSAP00000008584 | ENSCSAP00000008910 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.843 |
| HERC1 | MDN1 | ENSCSAP00000008584 | ENSCSAP00000013324 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. | 0.831 |
| HERC1 | NEURL1B | ENSCSAP00000008584 | ENSCSAP00000005853 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Neuralized E3 ubiquitin protein ligase 1B. | 0.665 |
| HERC1 | NEURL4 | ENSCSAP00000008584 | ENSCSAP00000008002 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Neuralized E3 ubiquitin protein ligase 4. | 0.733 |
| HERC1 | PIAS4 | ENSCSAP00000008584 | ENSCSAP00000007004 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Protein inhibitor of activated STAT 4. | 0.748 |
| HERC1 | RNF8 | ENSCSAP00000008584 | ENSCSAP00000006706 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.831 |
| HERC1 | TP53 | ENSCSAP00000008584 | ENSCSAP00000007551 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.710 |
| HERC1 | UBE3A | ENSCSAP00000008584 | ENSCSAP00000002712 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. | 0.732 |
| MDN1 | GEM | ENSCSAP00000013324 | ENSCSAP00000008910 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.824 |
| MDN1 | HERC1 | ENSCSAP00000013324 | ENSCSAP00000008584 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.831 |
