| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EP300 | HDAC3 | ENSCSAP00000002153 | ENSCSAP00000008654 | E1A binding protein p300. | Hist_deacetyl domain-containing protein. | 0.930 |
| EP300 | HDAC4 | ENSCSAP00000002153 | ENSCSAP00000002314 | E1A binding protein p300. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.651 |
| EP300 | KDM1A | ENSCSAP00000002153 | ENSCSAP00000017088 | E1A binding protein p300. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.672 |
| EP300 | NCOR1 | ENSCSAP00000002153 | ENSCSAP00000004853 | E1A binding protein p300. | Nuclear receptor corepressor 1. | 0.836 |
| EP300 | NCOR2 | ENSCSAP00000002153 | ENSCSAP00000016047 | E1A binding protein p300. | Nuclear receptor corepressor 2. | 0.666 |
| EP300 | PPARG | ENSCSAP00000002153 | ENSCSAP00000006082 | E1A binding protein p300. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.961 |
| EP300 | SIN3A | ENSCSAP00000002153 | ENSCSAP00000010639 | E1A binding protein p300. | SIN3 transcription regulator family member A. | 0.539 |
| EP300 | STAT3 | ENSCSAP00000002153 | ENSCSAP00000014828 | E1A binding protein p300. | Signal transducer and activator of transcription. | 0.998 |
| EP300 | TBL1X | ENSCSAP00000002153 | ENSCSAP00000011440 | E1A binding protein p300. | Transducin beta like 1 X-linked. | 0.436 |
| EP300 | TBL1XR1 | ENSCSAP00000002153 | ENSCSAP00000009102 | E1A binding protein p300. | Transducin beta like 1 X-linked receptor 1. | 0.446 |
| HDAC3 | EP300 | ENSCSAP00000008654 | ENSCSAP00000002153 | Hist_deacetyl domain-containing protein. | E1A binding protein p300. | 0.930 |
| HDAC3 | HDAC4 | ENSCSAP00000008654 | ENSCSAP00000002314 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.950 |
| HDAC3 | KDM1A | ENSCSAP00000008654 | ENSCSAP00000017088 | Hist_deacetyl domain-containing protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.914 |
| HDAC3 | NCOR1 | ENSCSAP00000008654 | ENSCSAP00000004853 | Hist_deacetyl domain-containing protein. | Nuclear receptor corepressor 1. | 0.999 |
| HDAC3 | NCOR2 | ENSCSAP00000008654 | ENSCSAP00000016047 | Hist_deacetyl domain-containing protein. | Nuclear receptor corepressor 2. | 0.991 |
| HDAC3 | PPARG | ENSCSAP00000008654 | ENSCSAP00000006082 | Hist_deacetyl domain-containing protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.911 |
| HDAC3 | SIN3A | ENSCSAP00000008654 | ENSCSAP00000010639 | Hist_deacetyl domain-containing protein. | SIN3 transcription regulator family member A. | 0.952 |
| HDAC3 | STAT3 | ENSCSAP00000008654 | ENSCSAP00000014828 | Hist_deacetyl domain-containing protein. | Signal transducer and activator of transcription. | 0.895 |
| HDAC3 | TBL1X | ENSCSAP00000008654 | ENSCSAP00000011440 | Hist_deacetyl domain-containing protein. | Transducin beta like 1 X-linked. | 0.945 |
| HDAC3 | TBL1XR1 | ENSCSAP00000008654 | ENSCSAP00000009102 | Hist_deacetyl domain-containing protein. | Transducin beta like 1 X-linked receptor 1. | 0.985 |
