| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK3 | AK9 | ENSCSAP00000005054 | ENSCSAP00000011452 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Adenylate kinase 9. | 0.959 |
| AK3 | CMPK1 | ENSCSAP00000005054 | ENSCSAP00000016765 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.544 |
| AK3 | CMPK2 | ENSCSAP00000005054 | ENSCSAP00000003310 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Cytidine/uridine monophosphate kinase 2. | 0.523 |
| AK3 | DTYMK | ENSCSAP00000005054 | ENSCSAP00000002062 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Deoxythymidylate kinase. | 0.498 |
| AK3 | NME1 | ENSCSAP00000005054 | ENSCSAP00000001821 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.940 |
| AK3 | NME2 | ENSCSAP00000005054 | ENSCSAP00000001822 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.940 |
| AK3 | NME3 | ENSCSAP00000005054 | ENSCSAP00000007659 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.940 |
| AK3 | NME4 | ENSCSAP00000005054 | ENSCSAP00000008974 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Nucleoside diphosphate kinase. | 0.960 |
| AK3 | RRM1 | ENSCSAP00000005054 | ENSCSAP00000000608 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.954 |
| AK9 | AK3 | ENSCSAP00000011452 | ENSCSAP00000005054 | Adenylate kinase 9. | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 0.959 |
| AK9 | CMPK1 | ENSCSAP00000011452 | ENSCSAP00000016765 | Adenylate kinase 9. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.961 |
| AK9 | CMPK2 | ENSCSAP00000011452 | ENSCSAP00000003310 | Adenylate kinase 9. | Cytidine/uridine monophosphate kinase 2. | 0.957 |
| AK9 | DTYMK | ENSCSAP00000011452 | ENSCSAP00000002062 | Adenylate kinase 9. | Deoxythymidylate kinase. | 0.957 |
| AK9 | ITPA | ENSCSAP00000011452 | ENSCSAP00000009450 | Adenylate kinase 9. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.933 |
| AK9 | NME1 | ENSCSAP00000011452 | ENSCSAP00000001821 | Adenylate kinase 9. | Nucleoside diphosphate kinase. | 0.955 |
| AK9 | NME2 | ENSCSAP00000011452 | ENSCSAP00000001822 | Adenylate kinase 9. | Nucleoside diphosphate kinase. | 0.955 |
| AK9 | NME3 | ENSCSAP00000011452 | ENSCSAP00000007659 | Adenylate kinase 9. | Nucleoside diphosphate kinase. | 0.955 |
| AK9 | NME4 | ENSCSAP00000011452 | ENSCSAP00000008974 | Adenylate kinase 9. | Nucleoside diphosphate kinase. | 0.955 |
| AK9 | RRM1 | ENSCSAP00000011452 | ENSCSAP00000000608 | Adenylate kinase 9. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.980 |
| CMPK1 | AK3 | ENSCSAP00000016765 | ENSCSAP00000005054 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 0.544 |
