| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EGR1 | EGR2 | ENSCSAP00000009282 | ENSCSAP00000003695 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Early growth response 2. | 0.967 |
| EGR1 | ENSCSAP00000014866 | ENSCSAP00000009282 | ENSCSAP00000014866 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Uncharacterized protein. | 0.962 |
| EGR1 | EP300 | ENSCSAP00000009282 | ENSCSAP00000002153 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | E1A binding protein p300. | 0.848 |
| EGR1 | FOS | ENSCSAP00000009282 | ENSCSAP00000008321 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.980 |
| EGR1 | JUN | ENSCSAP00000009282 | ENSCSAP00000017843 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.959 |
| EGR1 | JUNB | ENSCSAP00000009282 | ENSCSAP00000018357 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | JunB proto-oncogene, AP-1 transcription factor subunit. | 0.931 |
| EGR1 | MAPK1 | ENSCSAP00000009282 | ENSCSAP00000009828 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.923 |
| EGR1 | MAPK3 | ENSCSAP00000009282 | ENSCSAP00000002490 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.933 |
| EGR1 | NAB2 | ENSCSAP00000009282 | ENSCSAP00000001300 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | NGFI-A binding protein 2. | 0.857 |
| EGR1 | TP53 | ENSCSAP00000009282 | ENSCSAP00000007551 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.896 |
| EGR2 | EGR1 | ENSCSAP00000003695 | ENSCSAP00000009282 | Early growth response 2. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.967 |
| EGR2 | ENSCSAP00000014866 | ENSCSAP00000003695 | ENSCSAP00000014866 | Early growth response 2. | Uncharacterized protein. | 0.833 |
| EGR2 | EP300 | ENSCSAP00000003695 | ENSCSAP00000002153 | Early growth response 2. | E1A binding protein p300. | 0.923 |
| EGR2 | FOS | ENSCSAP00000003695 | ENSCSAP00000008321 | Early growth response 2. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.698 |
| EGR2 | JUN | ENSCSAP00000003695 | ENSCSAP00000017843 | Early growth response 2. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.546 |
| EGR2 | JUNB | ENSCSAP00000003695 | ENSCSAP00000018357 | Early growth response 2. | JunB proto-oncogene, AP-1 transcription factor subunit. | 0.482 |
| EGR2 | NAB2 | ENSCSAP00000003695 | ENSCSAP00000001300 | Early growth response 2. | NGFI-A binding protein 2. | 0.973 |
| ENSCSAP00000014866 | EGR1 | ENSCSAP00000014866 | ENSCSAP00000009282 | Uncharacterized protein. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.962 |
| ENSCSAP00000014866 | EGR2 | ENSCSAP00000014866 | ENSCSAP00000003695 | Uncharacterized protein. | Early growth response 2. | 0.833 |
| ENSCSAP00000014866 | FOS | ENSCSAP00000014866 | ENSCSAP00000008321 | Uncharacterized protein. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.996 |
