| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD14 | LY96 | ENSCSAP00000008926 | ENSCSAP00000009668 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lymphocyte antigen 96. | 0.963 |
| CD14 | TLR2 | ENSCSAP00000008926 | ENSCSAP00000017617 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.975 |
| CD14 | TLR4 | ENSCSAP00000008926 | ENSCSAP00000009311 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.972 |
| CD14 | TLR6 | ENSCSAP00000008926 | ENSCSAP00000019187 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.466 |
| ENSCSAP00000018133 | LY96 | ENSCSAP00000018133 | ENSCSAP00000009668 | Uncharacterized protein. | Lymphocyte antigen 96. | 0.721 |
| ENSCSAP00000018133 | TLR2 | ENSCSAP00000018133 | ENSCSAP00000017617 | Uncharacterized protein. | Toll-like receptor. | 0.940 |
| ENSCSAP00000018133 | TLR4 | ENSCSAP00000018133 | ENSCSAP00000009311 | Uncharacterized protein. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.986 |
| IRAK4 | LY96 | ENSCSAP00000003071 | ENSCSAP00000009668 | Interleukin 1 receptor associated kinase 4. | Lymphocyte antigen 96. | 0.473 |
| IRAK4 | MYD88 | ENSCSAP00000003071 | ENSCSAP00000010525 | Interleukin 1 receptor associated kinase 4. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK4 | TICAM1 | ENSCSAP00000003071 | ENSCSAP00000018338 | Interleukin 1 receptor associated kinase 4. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.936 |
| IRAK4 | TICAM2 | ENSCSAP00000003071 | ENSCSAP00000017492 | Interleukin 1 receptor associated kinase 4. | Toll like receptor adaptor molecule 2. | 0.412 |
| IRAK4 | TIRAP | ENSCSAP00000003071 | ENSCSAP00000015776 | Interleukin 1 receptor associated kinase 4. | TIR domain containing adaptor protein. | 0.988 |
| IRAK4 | TLR2 | ENSCSAP00000003071 | ENSCSAP00000017617 | Interleukin 1 receptor associated kinase 4. | Toll-like receptor. | 0.685 |
| IRAK4 | TLR4 | ENSCSAP00000003071 | ENSCSAP00000009311 | Interleukin 1 receptor associated kinase 4. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.984 |
| IRAK4 | TLR6 | ENSCSAP00000003071 | ENSCSAP00000019187 | Interleukin 1 receptor associated kinase 4. | Toll-like receptor. | 0.413 |
| LY96 | CD14 | ENSCSAP00000009668 | ENSCSAP00000008926 | Lymphocyte antigen 96. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.963 |
| LY96 | ENSCSAP00000018133 | ENSCSAP00000009668 | ENSCSAP00000018133 | Lymphocyte antigen 96. | Uncharacterized protein. | 0.721 |
| LY96 | IRAK4 | ENSCSAP00000009668 | ENSCSAP00000003071 | Lymphocyte antigen 96. | Interleukin 1 receptor associated kinase 4. | 0.473 |
| LY96 | MYD88 | ENSCSAP00000009668 | ENSCSAP00000010525 | Lymphocyte antigen 96. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.967 |
| LY96 | TICAM1 | ENSCSAP00000009668 | ENSCSAP00000018338 | Lymphocyte antigen 96. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.952 |
