| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FOXO3 | MAPK1 | ENSCSAP00000011269 | ENSCSAP00000009828 | Forkhead box O3. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.943 |
| FOXO3 | SMAD2 | ENSCSAP00000011269 | ENSCSAP00000014035 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.966 |
| FOXO3 | SMAD3 | ENSCSAP00000011269 | ENSCSAP00000009443 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.987 |
| FOXO3 | SMAD4 | ENSCSAP00000011269 | ENSCSAP00000014115 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.797 |
| FOXO3 | SMAD9 | ENSCSAP00000011269 | ENSCSAP00000013893 | Forkhead box O3. | Mothers against decapentaplegic homolog. | 0.478 |
| MAPK1 | FOXO3 | ENSCSAP00000009828 | ENSCSAP00000011269 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Forkhead box O3. | 0.943 |
| MAPK1 | SMAD2 | ENSCSAP00000009828 | ENSCSAP00000014035 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.971 |
| MAPK1 | SMAD3 | ENSCSAP00000009828 | ENSCSAP00000009443 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.987 |
| MAPK1 | SMAD4 | ENSCSAP00000009828 | ENSCSAP00000014115 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.610 |
| MAPK1 | SMAD9 | ENSCSAP00000009828 | ENSCSAP00000013893 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Mothers against decapentaplegic homolog. | 0.947 |
| SMAD2 | FOXO3 | ENSCSAP00000014035 | ENSCSAP00000011269 | Mothers against decapentaplegic homolog. | Forkhead box O3. | 0.966 |
| SMAD2 | MAPK1 | ENSCSAP00000014035 | ENSCSAP00000009828 | Mothers against decapentaplegic homolog. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.971 |
| SMAD2 | SMAD3 | ENSCSAP00000014035 | ENSCSAP00000009443 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD4 | ENSCSAP00000014035 | ENSCSAP00000014115 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
| SMAD2 | SMAD7 | ENSCSAP00000014035 | ENSCSAP00000014041 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.991 |
| SMAD2 | SMAD9 | ENSCSAP00000014035 | ENSCSAP00000013893 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.982 |
| SMAD2 | SMURF2 | ENSCSAP00000014035 | ENSCSAP00000000389 | Mothers against decapentaplegic homolog. | SMAD specific E3 ubiquitin protein ligase 2. | 0.991 |
| SMAD2 | TGFBR1 | ENSCSAP00000014035 | ENSCSAP00000007285 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.998 |
| SMAD2 | TGFBR2 | ENSCSAP00000014035 | ENSCSAP00000005897 | Mothers against decapentaplegic homolog. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.989 |
| SMAD2 | ZFYVE9 | ENSCSAP00000014035 | ENSCSAP00000016742 | Mothers against decapentaplegic homolog. | Zinc finger FYVE domain-containing protein. | 0.998 |
