| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCND1 | CDK4 | ENSCSAP00000005529 | ENSCSAP00000000963 | Cyclin D1; Belongs to the cyclin family. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.999 |
| CCND1 | PCNA | ENSCSAP00000005529 | ENSCSAP00000009557 | Cyclin D1; Belongs to the cyclin family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.996 |
| CDK4 | CCND1 | ENSCSAP00000000963 | ENSCSAP00000005529 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Cyclin D1; Belongs to the cyclin family. | 0.999 |
| CDK4 | GADD45A | ENSCSAP00000000963 | ENSCSAP00000016651 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Growth arrest and DNA damage inducible alpha. | 0.460 |
| CDK4 | PCNA | ENSCSAP00000000963 | ENSCSAP00000009557 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.996 |
| CDK4 | RFC4 | ENSCSAP00000000963 | ENSCSAP00000005472 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Replication factor C subunit 4. | 0.439 |
| FEN1 | LIG1 | ENSCSAP00000002751 | ENSCSAP00000015138 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.953 |
| FEN1 | MSH6 | ENSCSAP00000002751 | ENSCSAP00000009745 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.931 |
| FEN1 | PCNA | ENSCSAP00000002751 | ENSCSAP00000009557 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.997 |
| FEN1 | RAD18 | ENSCSAP00000002751 | ENSCSAP00000007007 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RAD18 E3 ubiquitin protein ligase. | 0.467 |
| FEN1 | RFC2 | ENSCSAP00000002751 | ENSCSAP00000014213 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 2. | 0.907 |
| FEN1 | RFC3 | ENSCSAP00000002751 | ENSCSAP00000013917 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 3. | 0.947 |
| FEN1 | RFC4 | ENSCSAP00000002751 | ENSCSAP00000005472 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 4. | 0.938 |
| GADD45A | CDK4 | ENSCSAP00000016651 | ENSCSAP00000000963 | Growth arrest and DNA damage inducible alpha. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.460 |
| GADD45A | PCNA | ENSCSAP00000016651 | ENSCSAP00000009557 | Growth arrest and DNA damage inducible alpha. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |
| LIG1 | FEN1 | ENSCSAP00000015138 | ENSCSAP00000002751 | DNA ligase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.953 |
| LIG1 | MSH6 | ENSCSAP00000015138 | ENSCSAP00000009745 | DNA ligase. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.677 |
| LIG1 | PCNA | ENSCSAP00000015138 | ENSCSAP00000009557 | DNA ligase. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.993 |
| LIG1 | RFC2 | ENSCSAP00000015138 | ENSCSAP00000014213 | DNA ligase. | Replication factor C subunit 2. | 0.833 |
| LIG1 | RFC3 | ENSCSAP00000015138 | ENSCSAP00000013917 | DNA ligase. | Replication factor C subunit 3. | 0.908 |
