| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1 | ESR1 | ENSCSAP00000005949 | ENSCSAP00000010372 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Estrogen receptor 1. | 0.989 |
| AKT1 | ESR2 | ENSCSAP00000005949 | ENSCSAP00000009965 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Estrogen receptor 2. | 0.966 |
| AKT1 | JUN | ENSCSAP00000005949 | ENSCSAP00000017843 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.961 |
| AKT1 | SRC | ENSCSAP00000005949 | ENSCSAP00000009855 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Tyrosine-protein kinase. | 0.923 |
| ESR1 | AKT1 | ENSCSAP00000010372 | ENSCSAP00000005949 | Estrogen receptor 1. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.989 |
| ESR1 | ESR2 | ENSCSAP00000010372 | ENSCSAP00000009965 | Estrogen receptor 1. | Estrogen receptor 2. | 0.999 |
| ESR1 | JUN | ENSCSAP00000010372 | ENSCSAP00000017843 | Estrogen receptor 1. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.990 |
| ESR1 | MED1 | ENSCSAP00000010372 | ENSCSAP00000015361 | Estrogen receptor 1. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.996 |
| ESR1 | NCOA1 | ENSCSAP00000010372 | ENSCSAP00000004734 | Estrogen receptor 1. | Nuclear receptor coactivator. | 0.996 |
| ESR1 | NCOA2 | ENSCSAP00000010372 | ENSCSAP00000009995 | Estrogen receptor 1. | Nuclear receptor coactivator. | 0.994 |
| ESR1 | NCOA3 | ENSCSAP00000010372 | ENSCSAP00000011018 | Estrogen receptor 1. | Nuclear receptor coactivator. | 0.998 |
| ESR1 | NCOR1 | ENSCSAP00000010372 | ENSCSAP00000004853 | Estrogen receptor 1. | Nuclear receptor corepressor 1. | 0.995 |
| ESR1 | SP1 | ENSCSAP00000010372 | ENSCSAP00000001808 | Estrogen receptor 1. | Sp1 transcription factor. | 0.996 |
| ESR1 | SRC | ENSCSAP00000010372 | ENSCSAP00000009855 | Estrogen receptor 1. | Tyrosine-protein kinase. | 0.997 |
| ESR2 | AKT1 | ENSCSAP00000009965 | ENSCSAP00000005949 | Estrogen receptor 2. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.966 |
| ESR2 | ESR1 | ENSCSAP00000009965 | ENSCSAP00000010372 | Estrogen receptor 2. | Estrogen receptor 1. | 0.999 |
| ESR2 | JUN | ENSCSAP00000009965 | ENSCSAP00000017843 | Estrogen receptor 2. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.971 |
| ESR2 | MED1 | ENSCSAP00000009965 | ENSCSAP00000015361 | Estrogen receptor 2. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.990 |
| ESR2 | NCOA1 | ENSCSAP00000009965 | ENSCSAP00000004734 | Estrogen receptor 2. | Nuclear receptor coactivator. | 0.994 |
| ESR2 | NCOA2 | ENSCSAP00000009965 | ENSCSAP00000009995 | Estrogen receptor 2. | Nuclear receptor coactivator. | 0.979 |
