| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC45 | CDC6 | ENSCSAP00000007922 | ENSCSAP00000015262 | Cell division cycle 45. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.949 |
| CDC45 | CDT1 | ENSCSAP00000007922 | ENSCSAP00000015142 | Cell division cycle 45. | Chromatin licensing and DNA replication factor 1. | 0.984 |
| CDC45 | MCM2 | ENSCSAP00000007922 | ENSCSAP00000004719 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC45 | MCM3 | ENSCSAP00000007922 | ENSCSAP00000009229 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.989 |
| CDC45 | MCM4 | ENSCSAP00000007922 | ENSCSAP00000010927 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.994 |
| CDC45 | MCM5 | ENSCSAP00000007922 | ENSCSAP00000004447 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.989 |
| CDC45 | MCM6 | ENSCSAP00000007922 | ENSCSAP00000012379 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.995 |
| CDC45 | MCM7 | ENSCSAP00000007922 | ENSCSAP00000013867 | Cell division cycle 45. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.993 |
| CDC45 | ORC1 | ENSCSAP00000007922 | ENSCSAP00000016740 | Cell division cycle 45. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.983 |
| CDC45 | ORC6 | ENSCSAP00000007922 | ENSCSAP00000001868 | Cell division cycle 45. | Origin recognition complex subunit 6. | 0.971 |
| CDC6 | CDC45 | ENSCSAP00000015262 | ENSCSAP00000007922 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division cycle 45. | 0.949 |
| CDC6 | CDT1 | ENSCSAP00000015262 | ENSCSAP00000015142 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
| CDC6 | MCM2 | ENSCSAP00000015262 | ENSCSAP00000004719 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.992 |
| CDC6 | MCM3 | ENSCSAP00000015262 | ENSCSAP00000009229 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC6 | MCM4 | ENSCSAP00000015262 | ENSCSAP00000010927 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.989 |
| CDC6 | MCM5 | ENSCSAP00000015262 | ENSCSAP00000004447 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.986 |
| CDC6 | MCM6 | ENSCSAP00000015262 | ENSCSAP00000012379 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.989 |
| CDC6 | MCM7 | ENSCSAP00000015262 | ENSCSAP00000013867 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.995 |
| CDC6 | ORC1 | ENSCSAP00000015262 | ENSCSAP00000016740 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.997 |
| CDC6 | ORC6 | ENSCSAP00000015262 | ENSCSAP00000001868 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 6. | 0.996 |
