| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGAP4 | UBR3 | ENSCSAP00000003139 | ENSCSAP00000011157 | Rho GTPase activating protein 4. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.509 |
| ATE1 | UBR3 | ENSCSAP00000000973 | ENSCSAP00000011157 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.524 |
| ATMIN | UBR3 | ENSCSAP00000014479 | ENSCSAP00000011157 | ATM interactor. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.430 |
| CUL5 | TRIP12 | ENSCSAP00000015038 | ENSCSAP00000003303 | Cullin 5; Belongs to the cullin family. | Thyroid hormone receptor interactor 12. | 0.509 |
| CUL5 | UBR3 | ENSCSAP00000015038 | ENSCSAP00000011157 | Cullin 5; Belongs to the cullin family. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.596 |
| HECTD1 | TRIP12 | ENSCSAP00000011807 | ENSCSAP00000003303 | HECT domain E3 ubiquitin protein ligase 1. | Thyroid hormone receptor interactor 12. | 0.828 |
| HECTD1 | UBR3 | ENSCSAP00000011807 | ENSCSAP00000011157 | HECT domain E3 ubiquitin protein ligase 1. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.690 |
| KBTBD12 | UBR3 | ENSCSAP00000004824 | ENSCSAP00000011157 | Kelch repeat and BTB domain containing 12. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.437 |
| NEK2 | UBR3 | ENSCSAP00000011456 | ENSCSAP00000011157 | NIMA related kinase 2. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.516 |
| SIAH3 | UBR3 | ENSCSAP00000013787 | ENSCSAP00000011157 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.612 |
| TRIP12 | CUL5 | ENSCSAP00000003303 | ENSCSAP00000015038 | Thyroid hormone receptor interactor 12. | Cullin 5; Belongs to the cullin family. | 0.509 |
| TRIP12 | HECTD1 | ENSCSAP00000003303 | ENSCSAP00000011807 | Thyroid hormone receptor interactor 12. | HECT domain E3 ubiquitin protein ligase 1. | 0.828 |
| TRIP12 | UBR3 | ENSCSAP00000003303 | ENSCSAP00000011157 | Thyroid hormone receptor interactor 12. | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | 0.483 |
| TRIP12 | UBR7 | ENSCSAP00000003303 | ENSCSAP00000007418 | Thyroid hormone receptor interactor 12. | UBR-type domain-containing protein. | 0.510 |
| UBR3 | ARHGAP4 | ENSCSAP00000011157 | ENSCSAP00000003139 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Rho GTPase activating protein 4. | 0.509 |
| UBR3 | ATE1 | ENSCSAP00000011157 | ENSCSAP00000000973 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family. | 0.524 |
| UBR3 | ATMIN | ENSCSAP00000011157 | ENSCSAP00000014479 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | ATM interactor. | 0.430 |
| UBR3 | CUL5 | ENSCSAP00000011157 | ENSCSAP00000015038 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Cullin 5; Belongs to the cullin family. | 0.596 |
| UBR3 | HECTD1 | ENSCSAP00000011157 | ENSCSAP00000011807 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | HECT domain E3 ubiquitin protein ligase 1. | 0.690 |
| UBR3 | KBTBD12 | ENSCSAP00000011157 | ENSCSAP00000004824 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | Kelch repeat and BTB domain containing 12. | 0.437 |