node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNR1 | DRD2 | ENSCSAP00000017801 | ENSCSAP00000015239 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | 0.932 |
CNR1 | GNAI1 | ENSCSAP00000017801 | ENSCSAP00000008065 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | G protein subunit alpha i1. | 0.941 |
CNR1 | GNAO1 | ENSCSAP00000017801 | ENSCSAP00000001466 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | G protein subunit alpha o1. | 0.937 |
CNR1 | GNB1 | ENSCSAP00000017801 | ENSCSAP00000017306 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | G protein subunit beta 1. | 0.935 |
CNR1 | GNG2 | ENSCSAP00000017801 | ENSCSAP00000011177 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.933 |
DRD2 | CNR1 | ENSCSAP00000015239 | ENSCSAP00000017801 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | 0.932 |
DRD2 | GNAI1 | ENSCSAP00000015239 | ENSCSAP00000008065 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha i1. | 0.964 |
DRD2 | GNAO1 | ENSCSAP00000015239 | ENSCSAP00000001466 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha o1. | 0.977 |
DRD2 | GNB1 | ENSCSAP00000015239 | ENSCSAP00000017306 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 1. | 0.963 |
DRD2 | GNG2 | ENSCSAP00000015239 | ENSCSAP00000011177 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.935 |
DRD3 | GNAI1 | ENSCSAP00000003202 | ENSCSAP00000008065 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha i1. | 0.957 |
DRD3 | GNAO1 | ENSCSAP00000003202 | ENSCSAP00000001466 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha o1. | 0.961 |
DRD3 | GNB1 | ENSCSAP00000003202 | ENSCSAP00000017306 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 1. | 0.956 |
DRD3 | GNG2 | ENSCSAP00000003202 | ENSCSAP00000011177 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.935 |
GNAI1 | CNR1 | ENSCSAP00000008065 | ENSCSAP00000017801 | G protein subunit alpha i1. | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | 0.941 |
GNAI1 | DRD2 | ENSCSAP00000008065 | ENSCSAP00000015239 | G protein subunit alpha i1. | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. | 0.964 |
GNAI1 | DRD3 | ENSCSAP00000008065 | ENSCSAP00000003202 | G protein subunit alpha i1. | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | 0.957 |
GNAI1 | GNB1 | ENSCSAP00000008065 | ENSCSAP00000017306 | G protein subunit alpha i1. | G protein subunit beta 1. | 0.992 |
GNAI1 | GNG2 | ENSCSAP00000008065 | ENSCSAP00000011177 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.964 |
GNAI1 | HTR5A | ENSCSAP00000008065 | ENSCSAP00000002802 | G protein subunit alpha i1. | 5-hydroxytryptamine receptor 5A. | 0.950 |