Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FOXO3Forkhead box O3. (672 aa)    
Predicted Functional Partners:
SIRT1
Sirtuin 1.
    
 0.996
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.992
YWHAZ
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
    
 0.991
SMAD3
Mothers against decapentaplegic homolog.
    
 0.987
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
    
 0.982
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
    
 0.978
FOXO1
Forkhead box O1.
    
0.976
AKT2
Non-specific serine/threonine protein kinase.
    
 0.971
YWHAQ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family.
    
 0.970
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
   
 0.970
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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