node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FGF1 | FGF2 | ENSCSAP00000008567 | ENSCSAP00000000029 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.645 |
FGF1 | FGF8 | ENSCSAP00000008567 | ENSCSAP00000001820 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.461 |
FGF1 | FGFR2 | ENSCSAP00000008567 | ENSCSAP00000001011 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Fibroblast growth factor receptor. | 0.999 |
FGF1 | FGFR3 | ENSCSAP00000008567 | ENSCSAP00000011731 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Fibroblast growth factor receptor. | 0.979 |
FGF1 | GRB2 | ENSCSAP00000008567 | ENSCSAP00000001067 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Growth factor receptor bound protein 2. | 0.542 |
FGF1 | PIK3CA | ENSCSAP00000008567 | ENSCSAP00000009123 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.452 |
FGF1 | PLCG1 | ENSCSAP00000008567 | ENSCSAP00000010095 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Phosphoinositide phospholipase C. | 0.472 |
FGF1 | PLCG2 | ENSCSAP00000008567 | ENSCSAP00000014625 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.472 |
FGF2 | FGF1 | ENSCSAP00000000029 | ENSCSAP00000008567 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.645 |
FGF2 | FGF8 | ENSCSAP00000000029 | ENSCSAP00000001820 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.431 |
FGF2 | FGFR2 | ENSCSAP00000000029 | ENSCSAP00000001011 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.995 |
FGF2 | FGFR3 | ENSCSAP00000000029 | ENSCSAP00000011731 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.985 |
FGF2 | GRB2 | ENSCSAP00000000029 | ENSCSAP00000001067 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Growth factor receptor bound protein 2. | 0.453 |
FGF2 | PIK3CA | ENSCSAP00000000029 | ENSCSAP00000009123 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.451 |
FGF2 | PLCG1 | ENSCSAP00000000029 | ENSCSAP00000010095 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Phosphoinositide phospholipase C. | 0.403 |
FGF8 | FGF1 | ENSCSAP00000001820 | ENSCSAP00000008567 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.461 |
FGF8 | FGF2 | ENSCSAP00000001820 | ENSCSAP00000000029 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.431 |
FGF8 | FGFR2 | ENSCSAP00000001820 | ENSCSAP00000001011 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.999 |
FGF8 | FGFR3 | ENSCSAP00000001820 | ENSCSAP00000011731 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.969 |
FGF8 | GRB2 | ENSCSAP00000001820 | ENSCSAP00000001067 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Growth factor receptor bound protein 2. | 0.540 |