| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGO1 | AGO2 | ENSCSAP00000016922 | ENSCSAP00000005830 | Argonaute RISC component 1; Belongs to the argonaute family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.998 |
| AGO1 | DGCR8 | ENSCSAP00000016922 | ENSCSAP00000008179 | Argonaute RISC component 1; Belongs to the argonaute family. | DGCR8 microprocessor complex subunit. | 0.783 |
| AGO1 | DROSHA | ENSCSAP00000016922 | ENSCSAP00000013240 | Argonaute RISC component 1; Belongs to the argonaute family. | Drosha ribonuclease III. | 0.912 |
| AGO1 | ENSCSAP00000018397 | ENSCSAP00000016922 | ENSCSAP00000018397 | Argonaute RISC component 1; Belongs to the argonaute family. | Uncharacterized protein. | 0.818 |
| AGO1 | TARBP2 | ENSCSAP00000016922 | ENSCSAP00000001789 | Argonaute RISC component 1; Belongs to the argonaute family. | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.935 |
| AGO1 | XPO5 | ENSCSAP00000016922 | ENSCSAP00000008112 | Argonaute RISC component 1; Belongs to the argonaute family. | Exportin 5. | 0.808 |
| AGO2 | AGO1 | ENSCSAP00000005830 | ENSCSAP00000016922 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Argonaute RISC component 1; Belongs to the argonaute family. | 0.998 |
| AGO2 | DDX5 | ENSCSAP00000005830 | ENSCSAP00000000375 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.422 |
| AGO2 | DGCR8 | ENSCSAP00000005830 | ENSCSAP00000008179 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | DGCR8 microprocessor complex subunit. | 0.834 |
| AGO2 | DROSHA | ENSCSAP00000005830 | ENSCSAP00000013240 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Drosha ribonuclease III. | 0.945 |
| AGO2 | ENSCSAP00000018397 | ENSCSAP00000005830 | ENSCSAP00000018397 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein. | 0.952 |
| AGO2 | TARBP2 | ENSCSAP00000005830 | ENSCSAP00000001789 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.988 |
| AGO2 | XPO5 | ENSCSAP00000005830 | ENSCSAP00000008112 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Exportin 5. | 0.899 |
| DDX17 | DDX5 | ENSCSAP00000002935 | ENSCSAP00000000375 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.995 |
| DDX17 | DGCR8 | ENSCSAP00000002935 | ENSCSAP00000008179 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | DGCR8 microprocessor complex subunit. | 0.737 |
| DDX17 | DROSHA | ENSCSAP00000002935 | ENSCSAP00000013240 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | Drosha ribonuclease III. | 0.886 |
| DDX5 | AGO2 | ENSCSAP00000000375 | ENSCSAP00000005830 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.422 |
| DDX5 | DDX17 | ENSCSAP00000000375 | ENSCSAP00000002935 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | DEAD-box helicase 17; Belongs to the DEAD box helicase family. | 0.995 |
| DDX5 | DGCR8 | ENSCSAP00000000375 | ENSCSAP00000008179 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | DGCR8 microprocessor complex subunit. | 0.746 |
| DDX5 | DROSHA | ENSCSAP00000000375 | ENSCSAP00000013240 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | Drosha ribonuclease III. | 0.983 |
