| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBS | FLAD1 | ENSCSAP00000004297 | ENSCSAP00000016057 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.651 |
| CBS | MTHFR | ENSCSAP00000004297 | ENSCSAP00000017206 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.597 |
| CBS | MTR | ENSCSAP00000004297 | ENSCSAP00000005947 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.959 |
| CBS | MTRR | ENSCSAP00000004297 | ENSCSAP00000013365 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.803 |
| CBS | SMS | ENSCSAP00000004297 | ENSCSAP00000010563 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Spermine synthase. | 0.438 |
| FLAD1 | CBS | ENSCSAP00000016057 | ENSCSAP00000004297 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.651 |
| FLAD1 | MTRR | ENSCSAP00000016057 | ENSCSAP00000013365 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.716 |
| IGFBP7 | MTRR | ENSCSAP00000001458 | ENSCSAP00000013365 | Insulin like growth factor binding protein 7. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.754 |
| IGFBP7 | PROKR2 | ENSCSAP00000001458 | ENSCSAP00000009572 | Insulin like growth factor binding protein 7. | Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.742 |
| IGFBP7 | ZC3HAV1 | ENSCSAP00000001458 | ENSCSAP00000004772 | Insulin like growth factor binding protein 7. | Poly [ADP-ribose] polymerase. | 0.521 |
| MMACHC | MMADHC | ENSCSAP00000016799 | ENSCSAP00000012205 | Metabolism of cobalamin associated C. | Metabolism of cobalamin associated D. | 0.989 |
| MMACHC | MTR | ENSCSAP00000016799 | ENSCSAP00000005947 | Metabolism of cobalamin associated C. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.843 |
| MMACHC | MTRR | ENSCSAP00000016799 | ENSCSAP00000013365 | Metabolism of cobalamin associated C. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.758 |
| MMADHC | MMACHC | ENSCSAP00000012205 | ENSCSAP00000016799 | Metabolism of cobalamin associated D. | Metabolism of cobalamin associated C. | 0.989 |
| MMADHC | MTHFR | ENSCSAP00000012205 | ENSCSAP00000017206 | Metabolism of cobalamin associated D. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.465 |
| MMADHC | MTR | ENSCSAP00000012205 | ENSCSAP00000005947 | Metabolism of cobalamin associated D. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.904 |
| MMADHC | MTRR | ENSCSAP00000012205 | ENSCSAP00000013365 | Metabolism of cobalamin associated D. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.903 |
| MTHFR | CBS | ENSCSAP00000017206 | ENSCSAP00000004297 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.597 |
| MTHFR | MMADHC | ENSCSAP00000017206 | ENSCSAP00000012205 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Metabolism of cobalamin associated D. | 0.465 |
| MTHFR | MTR | ENSCSAP00000017206 | ENSCSAP00000005947 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.991 |
