Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)    
Predicted Functional Partners:
GIT1
GIT ArfGAP 1.
   
 0.999
PAK1
Non-specific serine/threonine protein kinase.
   
 0.997
PAK2
Non-specific serine/threonine protein kinase.
   
 0.996
CDC42
Cell division cycle 42.
   
 0.996
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
   
0.994
PAK3
Non-specific serine/threonine protein kinase.
   
 0.989
RAC3
Rac family small GTPase 3.
   
 0.985
PXN
Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.
    
 0.983
GIT2
GIT ArfGAP 2.
   
 0.980
RAC2
Rac family small GTPase 2.
   
 0.974
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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