| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATR | CDC45 | ENSCSAP00000007482 | ENSCSAP00000007922 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Cell division cycle 45. | 0.808 |
| ATR | CDC6 | ENSCSAP00000007482 | ENSCSAP00000015262 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.798 |
| ATR | MCM2 | ENSCSAP00000007482 | ENSCSAP00000004719 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | DNA helicase; Belongs to the MCM family. | 0.828 |
| ATR | MCM4 | ENSCSAP00000007482 | ENSCSAP00000010927 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | DNA helicase; Belongs to the MCM family. | 0.827 |
| ATR | PIEZO2 | ENSCSAP00000007482 | ENSCSAP00000013545 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Piezo-type mechanosensitive ion channel component. | 0.722 |
| ATR | TIMELESS | ENSCSAP00000007482 | ENSCSAP00000001412 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Timeless circadian regulator. | 0.707 |
| ATR | TIPIN | ENSCSAP00000007482 | ENSCSAP00000009317 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.779 |
| ATR | TP53BP1 | ENSCSAP00000007482 | ENSCSAP00000005376 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Tumor protein p53 binding protein 1. | 0.853 |
| ATR | WDHD1 | ENSCSAP00000007482 | ENSCSAP00000010793 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | WD repeat and HMG-box DNA binding protein 1. | 0.827 |
| CDC45 | ATR | ENSCSAP00000007922 | ENSCSAP00000007482 | Cell division cycle 45. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.808 |
| CDC45 | CDC6 | ENSCSAP00000007922 | ENSCSAP00000015262 | Cell division cycle 45. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.949 |
| CDC45 | MCM2 | ENSCSAP00000007922 | ENSCSAP00000004719 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC45 | MCM4 | ENSCSAP00000007922 | ENSCSAP00000010927 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.994 |
| CDC45 | PIEZO2 | ENSCSAP00000007922 | ENSCSAP00000013545 | Cell division cycle 45. | Piezo-type mechanosensitive ion channel component. | 0.775 |
| CDC45 | TIMELESS | ENSCSAP00000007922 | ENSCSAP00000001412 | Cell division cycle 45. | Timeless circadian regulator. | 0.894 |
| CDC45 | TIPIN | ENSCSAP00000007922 | ENSCSAP00000009317 | Cell division cycle 45. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.881 |
| CDC45 | TP53BP1 | ENSCSAP00000007922 | ENSCSAP00000005376 | Cell division cycle 45. | Tumor protein p53 binding protein 1. | 0.656 |
| CDC45 | WDHD1 | ENSCSAP00000007922 | ENSCSAP00000010793 | Cell division cycle 45. | WD repeat and HMG-box DNA binding protein 1. | 0.929 |
| CDC6 | ATR | ENSCSAP00000015262 | ENSCSAP00000007482 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.798 |
| CDC6 | CDC45 | ENSCSAP00000015262 | ENSCSAP00000007922 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division cycle 45. | 0.949 |
