| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GLUD1 | SIRT1 | ENSCSAP00000005979 | ENSCSAP00000003766 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Sirtuin 1. | 0.520 |
| GLUD1 | SIRT2 | ENSCSAP00000005979 | ENSCSAP00000000306 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.568 |
| GLUD1 | SIRT3 | ENSCSAP00000005979 | ENSCSAP00000007481 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.861 |
| GLUD1 | SIRT4 | ENSCSAP00000005979 | ENSCSAP00000015768 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.958 |
| GLUD1 | SIRT5 | ENSCSAP00000005979 | ENSCSAP00000003795 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.509 |
| GLUD1 | SIRT6 | ENSCSAP00000005979 | ENSCSAP00000006979 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Sirtuin 6. | 0.519 |
| GLUD1 | SIRT7 | ENSCSAP00000005979 | ENSCSAP00000015834 | ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Sirtuin 7. | 0.511 |
| NADSYN1 | NAMPT | ENSCSAP00000005682 | ENSCSAP00000007630 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.427 |
| NADSYN1 | NMNAT3 | ENSCSAP00000005682 | ENSCSAP00000007379 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Nicotinamide-nucleotide adenylyltransferase. | 0.983 |
| NADSYN1 | SIRT1 | ENSCSAP00000005682 | ENSCSAP00000003766 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Sirtuin 1. | 0.939 |
| NADSYN1 | SIRT2 | ENSCSAP00000005682 | ENSCSAP00000000306 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.924 |
| NADSYN1 | SIRT3 | ENSCSAP00000005682 | ENSCSAP00000007481 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.924 |
| NADSYN1 | SIRT4 | ENSCSAP00000005682 | ENSCSAP00000015768 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] | 0.924 |
| NADSYN1 | SIRT5 | ENSCSAP00000005682 | ENSCSAP00000003795 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.932 |
| NADSYN1 | SIRT6 | ENSCSAP00000005682 | ENSCSAP00000006979 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Sirtuin 6. | 0.924 |
| NADSYN1 | SIRT7 | ENSCSAP00000005682 | ENSCSAP00000015834 | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | Sirtuin 7. | 0.924 |
| NAMPT | NADSYN1 | ENSCSAP00000007630 | ENSCSAP00000005682 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.427 |
| NAMPT | NMNAT3 | ENSCSAP00000007630 | ENSCSAP00000007379 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Nicotinamide-nucleotide adenylyltransferase. | 0.960 |
| NAMPT | SIRT1 | ENSCSAP00000007630 | ENSCSAP00000003766 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Sirtuin 1. | 0.966 |
| NAMPT | SIRT2 | ENSCSAP00000007630 | ENSCSAP00000000306 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.946 |
