node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADL41384.1 | ADL42753.1 | COB47_0004 | COB47_1464 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | 0.585 |
ADL41384.1 | glyA | COB47_0004 | COB47_1465 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.421 |
ADL41384.1 | polA | COB47_0004 | COB47_1113 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.989 |
ADL41437.1 | ADL42753.1 | COB47_0061 | COB47_1464 | KEGG: ate:Athe_0064 Appr-1-p processing domain protein; PFAM: Appr-1-p processing domain protein; SMART: Appr-1-p processing domain protein. | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | 0.708 |
ADL41437.1 | polA | COB47_0061 | COB47_1113 | KEGG: ate:Athe_0064 Appr-1-p processing domain protein; PFAM: Appr-1-p processing domain protein; SMART: Appr-1-p processing domain protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.433 |
ADL42752.1 | ADL42753.1 | COB47_1463 | COB47_1464 | PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: ate:Athe_1062 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | 0.640 |
ADL42752.1 | ADL42755.1 | COB47_1463 | COB47_1466 | PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: ate:Athe_1062 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). | PFAM: protein of unknown function DUF1212; KEGG: ate:Athe_1059 protein of unknown function DUF1212. | 0.421 |
ADL42752.1 | glyA | COB47_1463 | COB47_1465 | PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: ate:Athe_1062 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.759 |
ADL42753.1 | ADL41384.1 | COB47_1464 | COB47_0004 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.585 |
ADL42753.1 | ADL41437.1 | COB47_1464 | COB47_0061 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | KEGG: ate:Athe_0064 Appr-1-p processing domain protein; PFAM: Appr-1-p processing domain protein; SMART: Appr-1-p processing domain protein. | 0.708 |
ADL42753.1 | ADL42752.1 | COB47_1464 | COB47_1463 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: ate:Athe_1062 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). | 0.640 |
ADL42753.1 | ADL42755.1 | COB47_1464 | COB47_1466 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | PFAM: protein of unknown function DUF1212; KEGG: ate:Athe_1059 protein of unknown function DUF1212. | 0.471 |
ADL42753.1 | ADL42756.1 | COB47_1464 | COB47_1467 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | KEGG: ate:Athe_1058 hypothetical protein. | 0.472 |
ADL42753.1 | cinA | COB47_1464 | COB47_1528 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | KEGG: ate:Athe_0985 competence/damage-inducible protein CinA; TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; Belongs to the CinA family. | 0.546 |
ADL42753.1 | glyA | COB47_1464 | COB47_1465 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.829 |
ADL42753.1 | guaA | COB47_1464 | COB47_1122 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.540 |
ADL42753.1 | nadE | COB47_1464 | COB47_0220 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.610 |
ADL42753.1 | polA | COB47_1464 | COB47_1113 | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.658 |
ADL42755.1 | ADL42752.1 | COB47_1466 | COB47_1463 | PFAM: protein of unknown function DUF1212; KEGG: ate:Athe_1059 protein of unknown function DUF1212. | PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: ate:Athe_1062 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). | 0.421 |
ADL42755.1 | ADL42753.1 | COB47_1466 | COB47_1464 | PFAM: protein of unknown function DUF1212; KEGG: ate:Athe_1059 protein of unknown function DUF1212. | KEGG: ate:Athe_1061 AAA ATPase central domain protein; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. | 0.471 |