Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (118 aa)    
Predicted Functional Partners:
hypB
Hydrogenase accessory protein.
 
 
 0.995
hypF
Hydrogenase maturation protein.
 
   
 0.953
hypE
Hydrogenase expression/formation protein.
 
  
 0.951
hupL2
Ni,Fe-hydrogenase large subunit.
 
 
 0.915
hycE
NADH dehydrogenase/hydrogenase large subunit.
  
 
 0.827
hypD
Hydrogenase expression/formation protein.
 
  
 0.816
hupS2
Ni,Fe-hydrogenase small subunit.
  
  
 0.789
hypX
Hydrogenase maturation factor; Belongs to the enoyl-CoA hydratase/isomerase family.
 
    0.786
mrp
ATP/GTP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.709
hypC
Hydrogenase assembly chaperone.
 
  
 0.700
Your Current Organism:
Hydrogenobacter thermophilus
NCBI taxonomy Id: 608538
Other names: H. thermophilus TK-6, Hydrogenobacter thermophilus DSM 6534, Hydrogenobacter thermophilus TK-6, Hydrogenobacter thermophilus str. TK-6, Hydrogenobacter thermophilus strain TK-6
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.