node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HTH_0076 | trpA | HTH_0076 | HTH_1703 | Anthranilate synthase component II. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.935 |
HTH_0076 | trpB1 | HTH_0076 | HTH_1036 | Anthranilate synthase component II. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.909 |
HTH_0076 | trpC | HTH_0076 | HTH_0109 | Anthranilate synthase component II. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.995 |
HTH_0076 | trpD | HTH_0076 | HTH_1488 | Anthranilate synthase component II. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
HTH_0076 | trpE | HTH_0076 | HTH_0771 | Anthranilate synthase component II. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
HTH_0076 | trpF | HTH_0076 | HTH_0191 | Anthranilate synthase component II. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.993 |
glyA | pgmA | HTH_1832 | HTH_0103 | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | 0.916 |
glyA | pspB | HTH_1832 | HTH_0183 | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | Phosphoglycerate mutase; Part of a complex that catalyzes the dephosphorylation of L- phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | 0.916 |
glyA | trpA | HTH_1832 | HTH_1703 | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.926 |
glyA | trpB1 | HTH_1832 | HTH_1036 | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.928 |
glyA | trpB2 | HTH_1832 | HTH_1065 | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.905 |
pgmA | glyA | HTH_0103 | HTH_1832 | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | 0.916 |
pgmA | pspB | HTH_0103 | HTH_0183 | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Phosphoglycerate mutase; Part of a complex that catalyzes the dephosphorylation of L- phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | 0.912 |
pgmA | trpA | HTH_0103 | HTH_1703 | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
pgmA | trpB1 | HTH_0103 | HTH_1036 | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
pgmA | trpB2 | HTH_0103 | HTH_1065 | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
pspB | glyA | HTH_0183 | HTH_1832 | Phosphoglycerate mutase; Part of a complex that catalyzes the dephosphorylation of L- phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Glycine/serine hydroxymethyltransferase; Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo- threonine, L-threo-beta-phenyls [...] | 0.916 |
pspB | pgmA | HTH_0183 | HTH_0103 | Phosphoglycerate mutase; Part of a complex that catalyzes the dephosphorylation of L- phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Phosphoglycerate mutase; Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D- phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para- nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | 0.912 |
pspB | trpA | HTH_0183 | HTH_1703 | Phosphoglycerate mutase; Part of a complex that catalyzes the dephosphorylation of L- phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
pspB | trpB1 | HTH_0183 | HTH_1036 | Phosphoglycerate mutase; Part of a complex that catalyzes the dephosphorylation of L- phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |