node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADL04440.1 | ADL04442.1 | Closa_1857 | Closa_1859 | PFAM: phosphatidate cytidylyltransferase; KEGG: cpy:Cphy_2623 phosphatidate cytidylyltransferase; Belongs to the CDS family. | TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; KEGG: ere:EUBREC_1766 putative membrane-associated Zn-dependent protease; SMART: PDZ/DHR/GLGF domain protein. | 0.874 |
ADL04440.1 | dxr | Closa_1857 | Closa_1858 | PFAM: phosphatidate cytidylyltransferase; KEGG: cpy:Cphy_2623 phosphatidate cytidylyltransferase; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.916 |
ADL04440.1 | ispG | Closa_1857 | Closa_1860 | PFAM: phosphatidate cytidylyltransferase; KEGG: cpy:Cphy_2623 phosphatidate cytidylyltransferase; Belongs to the CDS family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.661 |
ADL04440.1 | polC | Closa_1857 | Closa_1861 | PFAM: phosphatidate cytidylyltransferase; KEGG: cpy:Cphy_2623 phosphatidate cytidylyltransferase; Belongs to the CDS family. | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.645 |
ADL04442.1 | ADL04440.1 | Closa_1859 | Closa_1857 | TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; KEGG: ere:EUBREC_1766 putative membrane-associated Zn-dependent protease; SMART: PDZ/DHR/GLGF domain protein. | PFAM: phosphatidate cytidylyltransferase; KEGG: cpy:Cphy_2623 phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.874 |
ADL04442.1 | dxr | Closa_1859 | Closa_1858 | TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; KEGG: ere:EUBREC_1766 putative membrane-associated Zn-dependent protease; SMART: PDZ/DHR/GLGF domain protein. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.926 |
ADL04442.1 | ispG | Closa_1859 | Closa_1860 | TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; KEGG: ere:EUBREC_1766 putative membrane-associated Zn-dependent protease; SMART: PDZ/DHR/GLGF domain protein. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.696 |
ADL04442.1 | polC | Closa_1859 | Closa_1861 | TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; KEGG: ere:EUBREC_1766 putative membrane-associated Zn-dependent protease; SMART: PDZ/DHR/GLGF domain protein. | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.658 |
ADL06599.1 | dxr | Closa_4090 | Closa_1858 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.481 |
ADL06599.1 | dxs | Closa_4090 | Closa_3236 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.642 |
ADL06599.1 | ispD | Closa_4090 | Closa_0629 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.518 |
ADL06599.1 | ispE | Closa_4090 | Closa_0519 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.552 |
ADL06599.1 | ispF | Closa_4090 | Closa_1295 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.524 |
ADL06599.1 | ispG | Closa_4090 | Closa_1860 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.653 |
ADL06599.1 | ispH | Closa_4090 | Closa_0959 | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.909 |
dxr | ADL04440.1 | Closa_1858 | Closa_1857 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | PFAM: phosphatidate cytidylyltransferase; KEGG: cpy:Cphy_2623 phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.916 |
dxr | ADL04442.1 | Closa_1858 | Closa_1859 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; KEGG: ere:EUBREC_1766 putative membrane-associated Zn-dependent protease; SMART: PDZ/DHR/GLGF domain protein. | 0.926 |
dxr | ADL06599.1 | Closa_1858 | Closa_4090 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | PFAM: RNA binding S1 domain protein; KEGG: cpy:Cphy_0021 RNA-binding S1 domain-containing protein. | 0.481 |
dxr | dxs | Closa_1858 | Closa_3236 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.988 |
dxr | ispD | Closa_1858 | Closa_0629 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.987 |