node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BU064_03855 | BU064_07590 | GCA_001902315_01792 | GCA_001902315_00705 | Unannotated protein. | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.923 |
BU064_03855 | folD | GCA_001902315_01792 | GCA_001902315_01114 | Unannotated protein. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.948 |
BU064_03855 | gcvT | GCA_001902315_01792 | GCA_001902315_00612 | Unannotated protein. | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
BU064_03855 | glyA | GCA_001902315_01792 | GCA_001902315_00047 | Unannotated protein. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
BU064_03855 | purD | GCA_001902315_01792 | GCA_001902315_01103 | Unannotated protein. | Unannotated protein; Belongs to the GARS family. | 0.609 |
BU064_03855 | purN | GCA_001902315_01792 | GCA_001902315_01105 | Unannotated protein. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.933 |
BU064_03855 | purU | GCA_001902315_01792 | GCA_001902315_00263 | Unannotated protein. | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.934 |
BU064_07590 | BU064_03855 | GCA_001902315_00705 | GCA_001902315_01792 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein. | 0.923 |
BU064_07590 | folD | GCA_001902315_00705 | GCA_001902315_01114 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.407 |
BU064_07590 | gcvT | GCA_001902315_00705 | GCA_001902315_00612 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.896 |
BU064_07590 | glyA | GCA_001902315_00705 | GCA_001902315_00047 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
BU064_07590 | purD | GCA_001902315_00705 | GCA_001902315_01103 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Belongs to the GARS family. | 0.447 |
BU064_07590 | purN | GCA_001902315_00705 | GCA_001902315_01105 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.898 |
BU064_07590 | purU | GCA_001902315_00705 | GCA_001902315_00263 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.898 |
folD | BU064_03855 | GCA_001902315_01114 | GCA_001902315_01792 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein. | 0.948 |
folD | BU064_07590 | GCA_001902315_01114 | GCA_001902315_00705 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.407 |
folD | gcvT | GCA_001902315_01114 | GCA_001902315_00612 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.947 |
folD | glyA | GCA_001902315_01114 | GCA_001902315_00047 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
folD | purD | GCA_001902315_01114 | GCA_001902315_01103 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Belongs to the GARS family. | 0.917 |
folD | purN | GCA_001902315_01114 | GCA_001902315_01105 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.990 |