STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4Erb-b2 receptor tyrosine kinase 4. (1308 aa)    
Predicted Functional Partners:
NRG1
Neuregulin 1.
    
 0.999
NRG2
Neuregulin 2.
    
 0.993
ERBB2
Erb-b2 receptor tyrosine kinase 2.
  
 
0.993
EREG
Epiregulin.
    
 0.992
HBEGF
Heparin binding EGF like growth factor.
    
 0.987
GRB2
Growth factor receptor bound protein 2.
    
 0.987
EGF
Epidermal growth factor.
   
 0.986
BTC
Betacellulin.
    
 0.983
ERBB3
Erb-b2 receptor tyrosine kinase 3.
  
  
0.976
NRG4
Neuregulin 4.
   
 0.973
Your Current Organism:
Lynx canadensis
NCBI taxonomy Id: 61383
Other names: Canada lynx, Felis canadensis, L. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.