STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)    
Predicted Functional Partners:
RAP1B
RAP1B, member of RAS oncogene family.
    
 0.974
RAP1A
RAP1A, member of RAS oncogene family.
    
 0.974
RIMS2
Regulating synaptic membrane exocytosis 2.
    
 0.947
ABCC8
ATP binding cassette subfamily C member 8.
    
 0.945
ADCY2
Adenylate cyclase 2.
   
 
 0.939
ADCY4
Adenylate cyclase 4.
   
 
 0.935
ADCY6
Adenylate cyclase 6.
   
 
 0.934
ADCY8
Adenylate cyclase 8.
   
 
 0.931
RRAS2
RAS related 2.
    
 0.929
ADCY5
Adenylate cyclase 5.
   
 
 0.929
Your Current Organism:
Lynx canadensis
NCBI taxonomy Id: 61383
Other names: Canada lynx, Felis canadensis, L. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.