STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FOXO3Forkhead box O3. (672 aa)    
Predicted Functional Partners:
SIRT1
Sirtuin 1.
    
 0.986
AKT3
AKT serine/threonine kinase 3.
    
 0.963
SMAD2
SMAD family member 2.
    
 0.955
STAT3
Signal transducer and activator of transcription 3.
   
 0.955
SIRT3
Sirtuin 3.
    
 0.954
CDK2
Cyclin dependent kinase 2.
    
 0.946
ENSLCNP00005028923
annotation not available
    
 0.946
SGK1
Serum/glucocorticoid regulated kinase 1.
    
 0.944
AKT2
AKT serine/threonine kinase 2.
    
 0.944
YWHAQ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta.
    
 0.941
Your Current Organism:
Lynx canadensis
NCBI taxonomy Id: 61383
Other names: Canada lynx, Felis canadensis, L. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.