STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IST1IST1 factor associated with ESCRT-III. (366 aa)    
Predicted Functional Partners:
CHMP1A
Charged multivesicular body protein 1A.
    
 
 0.994
SPAST
Spastin.
    
 0.987
VPS4A
Vacuolar protein sorting 4 homolog A.
   
 0.974
CHMP5
Charged multivesicular body protein 5.
    
 
 0.960
VTA1
Vesicle trafficking 1.
   
 
 0.958
CHMP2A
Charged multivesicular body protein 2A.
    
 0.947
CHMP4C
Charged multivesicular body protein 4C.
    
 0.944
ENSLCNP00005023426
annotation not available
   
 0.936
ENSLCNP00005023442
annotation not available
   
 0.936
LOC115510806
E3 ubiquitin-protein ligase RNF103.
    
 0.926
Your Current Organism:
Lynx canadensis
NCBI taxonomy Id: 61383
Other names: Canada lynx, Felis canadensis, L. canadensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.