A0A1Y1W3A8 protein (Linderina pennispora) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A1Y1W3A8

Glycoside hydrolase. (760 aa)

Predicted Functional Partners:

A0A1Y1VXE4

0.731

A0A1Y1W2X8

0.693

A0A1Y1VQC0

0.616

A0A1Y1W2X0

0.616

A0A1Y1W2Y2

0.616

A0A1Y1VRE5

0.567

A0A1Y1WBX2

0.562

A0A1Y1WBF4

0.561

A0A1Y1W914

0.560

A0A1Y1W984

0.560

Your Current Organism:

Linderina pennispora

NCBI taxonomy Id: 61395
Other names: ATCC 12442, CBS 312.51, L. pennispora, NRRL 2237

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y1VQC0	A0A1Y1VRE5	Alkaline phosphatase-like protein.	Uncharacterized protein.	0.400
A0A1Y1VQC0	A0A1Y1VXE4	Alkaline phosphatase-like protein.	Uncharacterized protein.	0.577
A0A1Y1VQC0	A0A1Y1W2X8	Alkaline phosphatase-like protein.	Alkaline phosphatase-like protein.	0.682
A0A1Y1VQC0	A0A1Y1W3A8	Alkaline phosphatase-like protein.	Glycoside hydrolase.	0.616
A0A1Y1VQC0	A0A1Y1W914	Alkaline phosphatase-like protein.	Glycoside hydrolase family 20 protein.	0.400
A0A1Y1VQC0	A0A1Y1W984	Alkaline phosphatase-like protein.	Beta-hexosaminidase.	0.400
A0A1Y1VQC0	A0A1Y1WBF4	Alkaline phosphatase-like protein.	Beta-hexosaminidase.	0.400
A0A1Y1VQC0	A0A1Y1WBX2	Alkaline phosphatase-like protein.	Beta-hexosaminidase.	0.400
A0A1Y1VRE5	A0A1Y1VQC0	Uncharacterized protein.	Alkaline phosphatase-like protein.	0.400
A0A1Y1VRE5	A0A1Y1VXE4	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A1Y1VRE5	A0A1Y1W2X0	Uncharacterized protein.	Arylsulfatase.	0.400
A0A1Y1VRE5	A0A1Y1W2X8	Uncharacterized protein.	Alkaline phosphatase-like protein.	0.450
A0A1Y1VRE5	A0A1Y1W2Y2	Uncharacterized protein.	Arylsulfatase.	0.400
A0A1Y1VRE5	A0A1Y1W3A8	Uncharacterized protein.	Glycoside hydrolase.	0.567
A0A1Y1VXE4	A0A1Y1VQC0	Uncharacterized protein.	Alkaline phosphatase-like protein.	0.577
A0A1Y1VXE4	A0A1Y1VRE5	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A1Y1VXE4	A0A1Y1W2X0	Uncharacterized protein.	Arylsulfatase.	0.577
A0A1Y1VXE4	A0A1Y1W2Y2	Uncharacterized protein.	Arylsulfatase.	0.577
A0A1Y1VXE4	A0A1Y1W3A8	Uncharacterized protein.	Glycoside hydrolase.	0.731
A0A1Y1VXE4	A0A1Y1W914	Uncharacterized protein.	Glycoside hydrolase family 20 protein.	0.518

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.913

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

6 of 18

2.6

5.4

3.12e-11

GO:0015990

Electron transport coupled proton transport

2 of 2

3.08

1.58

0.0014

GO:0022607

Cellular component assembly

7 of 557

1.18

1.24

5.29e-05

GO:1902600

Proton transmembrane transport

3 of 120

1.48

0.74

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 25

2.28

2.57

1.02e-05

GO:0015399

Primary active transmembrane transporter activity

5 of 146

1.61

1.91

1.91e-05

GO:0048038

Quinone binding

2 of 10

2.38

1.2

0.0062

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

5 of 59

2.01

2.94

4.40e-07

GO:0005747

Mitochondrial respiratory chain complex I

4 of 25

2.28

2.93

1.74e-06

GO:0098798

Mitochondrial protein-containing complex

5 of 195

1.49

1.72

2.52e-05

GO:0005743

Mitochondrial inner membrane

5 of 272

1.34

1.39

0.00011

GO:0005739

Mitochondrion

10 of 1039

1.06

1.31

8.48e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10257

Respirasome, and NAD(P)H-binding

9 of 91

2.07

5.68

6.58e-15

CL:10427

NADH dehydrogenase complex assembly

4 of 6

2.9

4.4

7.21e-09

CL:10281

Complex I biogenesis

5 of 29

2.31

4.08

5.37e-09

CL:10284

Complex I biogenesis

4 of 24

2.3

3.18

5.29e-07

CL:10287

NADH dehydrogenase complex

3 of 17

2.32

2.27

4.46e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

6 of 148

1.69

2.6

1.56e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

8 of 34

2.45

7.16

8.18e-16

MAP-611105

Respiratory electron transport

8 of 68

2.15

5.63

6.49e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 82

2.07

5.24

1.77e-13

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 173

1.74

3.59

4.11e-11

MAP-1430728

Metabolism

9 of 2359

0.66

0.52

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

8 of 810

1.07

1.12

3.00e-05

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3298

0.56

0.42

0.0042

GOCC:0005737

Cytoplasm

10 of 3536

0.53

0.4

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 41

1.94

1.44

0.0014

KW-0004

4Fe-4S

2 of 12

2.3

1.16

0.0071

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.32

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006138

NADH-ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.08

0.0115

IPR006137

NADH:ubiquinone oxidoreductase-like, 20kDa subunit

2 of 2

3.08

1.08

0.0115

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