DL89DRAFT_7484 protein (Linderina pennispora)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

DL89DRAFT_7484

Uncharacterized protein. (624 aa)

Predicted Functional Partners:

A0A1Y1WN54

0.962

A0A1Y1WBP2

0.961

A0A1Y1W994

0.919

A0A1Y1VZS2

0.900

A0A1Y1W8Y2

0.896

A0A1Y1WLT1

0.874

A0A1Y1WM27

0.864

A0A1Y1W6F3

0.854

A0A1Y1WCA9

0.851

A0A1Y1WMT4

0.851

Your Current Organism:

Linderina pennispora

NCBI taxonomy Id: 61395
Other names: ATCC 12442, CBS 312.51, L. pennispora, NRRL 2237

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1Y1VZS2	A0A1Y1W6F3	A0A1Y1VZS2	A0A1Y1W6F3	RRM domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.837
A0A1Y1VZS2	A0A1Y1W8Y2	A0A1Y1VZS2	A0A1Y1W8Y2	RRM domain-containing protein.	Eukaryotic type KH-domain (KH-domain type I).	0.992
A0A1Y1VZS2	A0A1Y1W994	A0A1Y1VZS2	A0A1Y1W994	RRM domain-containing protein.	RRM domain-containing protein.	0.965
A0A1Y1VZS2	A0A1Y1WBP2	A0A1Y1VZS2	A0A1Y1WBP2	RRM domain-containing protein.	Uncharacterized protein.	0.989
A0A1Y1VZS2	A0A1Y1WCA9	A0A1Y1VZS2	A0A1Y1WCA9	RRM domain-containing protein.	Nuclear cap-binding protein subunit 2.	0.917
A0A1Y1VZS2	A0A1Y1WLT1	A0A1Y1VZS2	A0A1Y1WLT1	RRM domain-containing protein.	Zf-U1-domain-containing protein.	0.791
A0A1Y1VZS2	A0A1Y1WM27	A0A1Y1VZS2	A0A1Y1WM27	RRM domain-containing protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.972
A0A1Y1VZS2	A0A1Y1WMT4	A0A1Y1VZS2	A0A1Y1WMT4	RRM domain-containing protein.	L domain-like protein.	0.977
A0A1Y1VZS2	A0A1Y1WN54	A0A1Y1VZS2	A0A1Y1WN54	RRM domain-containing protein.	Uncharacterized protein.	0.968
A0A1Y1VZS2	DL89DRAFT_7484	A0A1Y1VZS2	A0A1Y1WK78	RRM domain-containing protein.	Uncharacterized protein.	0.900
A0A1Y1W6F3	A0A1Y1VZS2	A0A1Y1W6F3	A0A1Y1VZS2	P-loop containing nucleoside triphosphate hydrolase protein.	RRM domain-containing protein.	0.837
A0A1Y1W6F3	A0A1Y1W8Y2	A0A1Y1W6F3	A0A1Y1W8Y2	P-loop containing nucleoside triphosphate hydrolase protein.	Eukaryotic type KH-domain (KH-domain type I).	0.978
A0A1Y1W6F3	A0A1Y1W994	A0A1Y1W6F3	A0A1Y1W994	P-loop containing nucleoside triphosphate hydrolase protein.	RRM domain-containing protein.	0.758
A0A1Y1W6F3	A0A1Y1WBP2	A0A1Y1W6F3	A0A1Y1WBP2	P-loop containing nucleoside triphosphate hydrolase protein.	Uncharacterized protein.	0.714
A0A1Y1W6F3	A0A1Y1WCA9	A0A1Y1W6F3	A0A1Y1WCA9	P-loop containing nucleoside triphosphate hydrolase protein.	Nuclear cap-binding protein subunit 2.	0.974
A0A1Y1W6F3	A0A1Y1WLT1	A0A1Y1W6F3	A0A1Y1WLT1	P-loop containing nucleoside triphosphate hydrolase protein.	Zf-U1-domain-containing protein.	0.857
A0A1Y1W6F3	A0A1Y1WM27	A0A1Y1W6F3	A0A1Y1WM27	P-loop containing nucleoside triphosphate hydrolase protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.953
A0A1Y1W6F3	A0A1Y1WMT4	A0A1Y1W6F3	A0A1Y1WMT4	P-loop containing nucleoside triphosphate hydrolase protein.	L domain-like protein.	0.997
A0A1Y1W6F3	A0A1Y1WN54	A0A1Y1W6F3	A0A1Y1WN54	P-loop containing nucleoside triphosphate hydrolase protein.	Uncharacterized protein.	0.962
A0A1Y1W6F3	DL89DRAFT_7484	A0A1Y1W6F3	A0A1Y1WK78	P-loop containing nucleoside triphosphate hydrolase protein.	Uncharacterized protein.	0.854

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.879

expected number of edges:

42

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

5 of 22

1.87

2.29

9.82e-06

GO:0009408

Response to heat

3 of 10

1.99

1.23

0.0041

GO:0051603

Proteolysis involved in protein catabolic process

2 of 4

2.21

0.79

0.0344

GO:0050821

Protein stabilization

2 of 4

2.21

0.79

0.0344

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 48

1.61

2.14

2.81e-06

GO:0051082

Unfolded protein binding

3 of 10

1.99

1.36

0.0022

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.21

0.88

0.0237

GO:0004176

ATP-dependent peptidase activity

2 of 4

2.21

0.88

0.0237

GO:0140657

ATP-dependent activity

5 of 137

1.08

0.74

0.0085

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1235

0.46

0.38

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36350115

(2022) Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.

2 of 3

2.34

1.12

0.0086

PMID:32093084

(2020) Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus.

3 of 26

1.58

0.98

0.0086

PMID:33780465

(2021) Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA.

3 of 51

1.28

0.75

0.0186

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:378

Chaperone, and Cellular response to heat

10 of 16

2.31

7.89

5.09e-19

CL:381

Stress response, and Protein folding chaperone

8 of 10

2.42

6.85

2.99e-15

CL:384

Protein folding chaperone, and Chaperone binding

4 of 5

2.42

3.15

8.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236975

Antigen processing-Cross presentation

3 of 4

2.39

2.58

1.19e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

3 of 6

2.21

2.47

1.42e-05

MAP-1280218

Adaptive Immune System

3 of 6

2.21

2.47

1.42e-05

MAP-168256

Immune System

3 of 27

1.56

1.48

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 3

2.34

0.86

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

8 of 16

2.21

5.89

3.95e-14

KW-0143

Chaperone

5 of 23

1.85

2.62

9.96e-07

KW-0720

Serine protease

2 of 5

2.12

1.09

0.0088

KW-0645

Protease

3 of 34

1.46

0.93

0.0088

KW-0963

Cytoplasm

7 of 252

0.96

0.89

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00011

Hsp20/alpha crystallin family

3 of 3

2.51

1.95

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008978

HSP20-like chaperone

3 of 3

2.51

1.73

0.00064

IPR002068

Alpha crystallin/Hsp20 domain

3 of 3

2.51

1.73

0.00064

IPR037913

Small heat shock protein IbpA/IbpB, ACD domain

2 of 2

2.51

0.88

0.0255

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