STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fliTFlagellar biosynthesis protein FliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. (122 aa)    
Predicted Functional Partners:
fliS
Flagellar protein FliS; Flagellin specific chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.995
fliD
Flagellar hook protein FliD; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
 
 
 0.992
fliJ
Flagellar biosynthesis chaperone; Flagellar protein that affects chemotactic events. Belongs to the FliJ family.
  
 
 0.906
AKE09936.1
Flagellar biosynthesis protein FlgN; Export chaperone for FlgK and FlgL; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.842
flgK
With FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.825
fliH
Flagellar assembly protein H; Binds to and inhibits the function of flagella specific ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.813
fliZ
Flagellar biosynthesis protein FliZ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.786
flgL
With FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.770
flgM
Flagellar biosynthesis anti-sigma factor FlgM; Regulates the flagellar specific sigma28 transcription factor; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.753
flhD
Transcriptional regulator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family.
 
   
 0.726
Your Current Organism:
Serratia liquefaciens
NCBI taxonomy Id: 614
Other names: ATCC 27592, Aerobacter liquefaciens, CCUG 9285, CIP 103238, DSM 4487, LMG 7884, LMG:7884, NCTC 12962, S. liquefaciens
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